Population pharmacokinetics of the two enantiomers of tramadol and O-demethyl tramadol after surgery in children F. Bressolle, A. Rochette, S. Khier,

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Presentation transcript:

Population pharmacokinetics of the two enantiomers of tramadol and O-demethyl tramadol after surgery in children F. Bressolle, A. Rochette, S. Khier, C. Dadure, J. Ouaki, X. Capdevila British Journal of Anaesthesia Volume 102, Issue 3, Pages 390-399 (March 2009) DOI: 10.1093/bja/aen405 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 1 Model performance and diagnostic plots. Model-predicted vs observed plasma concentrations based on population parameter estimates (the line represents the line of identity). (a) (+)-Tramadol and (b) (−)-tramadol. British Journal of Anaesthesia 2009 102, 390-399DOI: (10.1093/bja/aen405) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 2 Model performance and diagnostic plots. Weighted residuals (WRES) vs predicted plasma concentrations. (a) (+)-Tramadol and (b) (−)- tramadol. British Journal of Anaesthesia 2009 102, 390-399DOI: (10.1093/bja/aen405) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 3 Plasma concentration–time profiles for (+)-tramadol and (+)-M1 in a 4-yr-old child. Lines are obtained from individual predicted concentrations connected point by point. British Journal of Anaesthesia 2009 102, 390-399DOI: (10.1093/bja/aen405) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 4 Distribution of metabolite/tramadol AUC ratios in the 24 children of the study. British Journal of Anaesthesia 2009 102, 390-399DOI: (10.1093/bja/aen405) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions