Calculation of the capnographic index based on expiratory molar mass–volume-curves — A suitable tool to screen for cystic fibrosis lung disease Susanne.

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Presentation transcript:

Calculation of the capnographic index based on expiratory molar mass–volume-curves — A suitable tool to screen for cystic fibrosis lung disease Susanne I. Fuchs, Sibylle Junge, Helmut Ellemunter, Manfred Ballmann, Monika Gappa Journal of Cystic Fibrosis Volume 12, Issue 3, Pages 277-283 (May 2013) DOI: 10.1016/j.jcf.2012.08.011 Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Molar mass–volume-curves derived from capnography in a patient with CF and a healthy control. MMss = side stream molar mass (g/mol). Journal of Cystic Fibrosis 2013 12, 277-283DOI: (10.1016/j.jcf.2012.08.011) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Individual capnographic index (KPIv=[S3/S2]∗100) versus age (years) in n=87 CF patients (●) and n=38 controls (○). Journal of Cystic Fibrosis 2013 12, 277-283DOI: (10.1016/j.jcf.2012.08.011) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 3 Individual capnographic index (KPIv=[S3/S2]∗100) versus lung clearance index (LCI=cumulative expired volume/functional residual capacity) in n=68/87 CF patients (●) vs. 38/38 controls (○). Vertical line: upper limit of normal of LCI (=7.0). Horizontal line: upper limit of normal of KPIv (=9.3). Journal of Cystic Fibrosis 2013 12, 277-283DOI: (10.1016/j.jcf.2012.08.011) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 4 Short term reproducibility of the capnographic index (KPIv=[S3/S2]∗100) in controls (n=20/21): mean KPIv of the 1st and the 2nd tests is plotted for each individual against the individual difference between the two tests. The solid line represents the mean difference between the two tests for the group; the broken lines cover two standard deviations above and below this mean difference. Journal of Cystic Fibrosis 2013 12, 277-283DOI: (10.1016/j.jcf.2012.08.011) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions