MYD88 L265P mutation and CDKN2A loss are early mutational events in primary central nervous system diffuse large B-cell lymphomas by Naema Nayyar, Michael.

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MYD88 L265P mutation and CDKN2A loss are early mutational events in primary central nervous system diffuse large B-cell lymphomas by Naema Nayyar, Michael D. White, Corey M. Gill, Matthew Lastrapes, Mia Bertalan, Alexander Kaplan, Megan R. D’Andrea, Ivanna Bihun, Andrew Kaneb, Jorg Dietrich, Judith A. Ferry, Maria Martinez-Lage, Anita Giobbie-Hurder, Darrell R. Borger, Fausto J. Rodriguez, Matthew P. Frosch, Emily Batchelor, Kaitlin Hoang, Benjamin Kuter, Sarah Fortin, Matthias Holdhoff, Daniel P. Cahill, Scott Carter, Priscilla K. Brastianos, and Tracy T. Batchelor BloodAdv Volume 3(3):375-383 February 12, 2019 © 2019 by The American Society of Hematology

Naema Nayyar et al. Blood Adv 2019;3:375-383 © 2019 by The American Society of Hematology

Somatic mutations in PCNSL Somatic mutations in PCNSL. Somatic mutations and copy-number aberrations in PCNSL. The plot includes primary (-P) and relapse samples (-R). Somatic mutations in PCNSL. Somatic mutations and copy-number aberrations in PCNSL. The plot includes primary (-P) and relapse samples (-R). The significance of mutations in each gene is shown to the right by a false discovery rate (FDR) q value. Naema Nayyar et al. Blood Adv 2019;3:375-383 © 2019 by The American Society of Hematology

Significant CNAs in the cohort. Significant CNAs in the cohort. Chromosomal regions of copy loss indicated in blue. Areas of copy gain indicated in red. Naema Nayyar et al. Blood Adv 2019;3:375-383 © 2019 by The American Society of Hematology

Phylogenetic trees. Phylogenetic trees. Phylogenetic trees from 4 different patients with relapsed PCNSL. (A-C) Comparison of the primary tumor with the relapsed specimen: primary and brain relapse (A), primary and systemic relapse (B), and primary and testicular relapse (C). (D) Comparison between simultaneous occurrence of brain and skin lymphoma. The width of each line corresponds to the CCF. Subpopulations (CCF <1) are labeled at the end of each line. The length of the line corresponds to the number of mutations that are present. Relevant mutations are indicated on each branch. Gray, shared; blue, private to primary tumor specimen in the CNS; purple, private to the relapsed or extracranial tumor specimen. Naema Nayyar et al. Blood Adv 2019;3:375-383 © 2019 by The American Society of Hematology