Selective phosphodiesterase-5 inhibition reduces neointimal hyperplasia in rat carotid arteries after surgical endarterectomy Kristóf Hirschberg, MD,

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Presentation transcript:

Selective phosphodiesterase-5 inhibition reduces neointimal hyperplasia in rat carotid arteries after surgical endarterectomy Kristóf Hirschberg, MD, Tamás Radovits, MD, PhD, Sivakkanan Loganathan, László Entz, MD, PhD, Carsten J. Beller, MD, Marie–Luise Gross, MD, Peter Sandner, PhD, Matthias Karck, MD, Gábor Szabó, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 137, Issue 6, Pages 1508-1514 (June 2009) DOI: 10.1016/j.jtcvs.2008.10.016 Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Morphometric results and representative histologic cross-sections from the different groups (hematoxylin and eosin staining). A, Percentage of stenosis (neointimal/original luminal area ratio). B, Neointimal/medial area ratio. C, Sham group. D, Control endarterectomy group with massive neointima proliferation. E, Significantly less neointima formation after treatment with vardenafil. ∗P < .05 vs sham operation; †P < .05 vs control endarterectomy. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 1508-1514DOI: (10.1016/j.jtcvs.2008.10.016) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Representative photomicrographs (B–C, E–F, and H–I) and semiquantitative scoring (A, D, and G) of immunohistochemical staining for transforming growth factor β1 (TGF-β1; red stain, A–C) and α-smooth muscle actin (Alpha-sm actin; brown stain, D–F) and for cyclic guanosine monophosphate (cGMP; red stain) in the neointima (G–I) are shown in the control endarterectomy group (B, E, and H) and the vardenafil treatment group (C, F, and I). m, media; ni, neointima. ∗P < .05 vs control endarterectomy. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 1508-1514DOI: (10.1016/j.jtcvs.2008.10.016) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Cyclic guanosine monophosphate (cGMP) plasma concentrations (in picomoles per milliliter) measured by means of competitive enzyme immunoassay in the different groups. ∗P < .05 vs unoperated control and control endarterectomy. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 1508-1514DOI: (10.1016/j.jtcvs.2008.10.016) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Terminal deoxynucleotidyl transferase–mediated dUTP-biotin nick end labeling (TUNEL)–positive cell count in 1000 μm2 of neointima in the control endarterectomy and vardenafil groups. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 1508-1514DOI: (10.1016/j.jtcvs.2008.10.016) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions