Volume 84, Issue 1, Pages (July 2013)

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Volume 84, Issue 1, Pages 164-173 (July 2013) The GFR and GFR decline cannot be accurately estimated in type 2 diabetics  Flavio Gaspari, Piero Ruggenenti, Esteban Porrini, Nicola Motterlini, Antonio Cannata, Fabiola Carrara, Alejandro Jiménez Sosa, Claudia Cella, Silvia Ferrari, Nadia Stucchi, Aneliya Parvanova, Ilian Iliev, Roberto Trevisan, Antonio Bossi, Jelka Zaletel, Giuseppe Remuzzi  Kidney International  Volume 84, Issue 1, Pages 164-173 (July 2013) DOI: 10.1038/ki.2013.47 Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 1 Bland–Altman plots of the difference between estimated glomerular filtration rate (eGFR) and measured glomerular filtration rate (mGFR) by the iohexol plasma clearance (mGFR) versus the mean of eGFR and mGFR for the Effersøe, Cockcroft–Gault, abbreviated Modification of Diet in Renal Disease (aMDRD), and Chronic Kidney Disease Epidemiology (CKD-EPI) formulas in the whole study group. The straight line and the dashed lines indicate mean difference and 95% limits of agreement, respectively. Kidney International 2013 84, 164-173DOI: (10.1038/ki.2013.47) Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 2 Detection of hyperfiltering patients at inclusion and of their short-term GFR reduction by estimation formulas. (a) Number of patients with measured glomerular filtration rate by iohexol plasma clearance or estimated glomerular filtration rate (eGFR) by different estimation formulas ≥120ml/min per 1.73m2 (Hyperfiltration) at inclusion. (b) Measured and estimated GFR changes from baseline to month 6 in hyperfiltering patients. Data are means. *P<0.0001 versus GFR changes estimated by all considered formulas. aMDRD, abbreviated Modification of Diet in Renal Disease; CKD-EPI, Chronic Kidney Disease Epidemiology. Kidney International 2013 84, 164-173DOI: (10.1038/ki.2013.47) Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 3 Measured and estimated rate of glomerular filtration rate (GFR) decline (slope) from month 6 to study end in the study group as a whole (overall) and in subgroups of hyperfiltering, normofiltering, and hypofiltering subjects considered separately. Data are medians. *P<0.0001; °P<0.001 versus measured GFR slopes. aMDRD, abbreviated Modification of Diet in Renal Disease; CKD-EPI, Chronic Kidney Disease Epidemiology. Kidney International 2013 84, 164-173DOI: (10.1038/ki.2013.47) Copyright © 2013 International Society of Nephrology Terms and Conditions