Adenovirus Virion Stability and the Viral Genome: Size Matters

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Adenovirus Virion Stability and the Viral Genome: Size Matters Michael A Kennedy, Robin J Parks Molecular Therapy Volume 17, Issue 10, Pages 1664-1666 (October 2009) DOI: 10.1038/mt.2009.202 Copyright © 2009 The American Society of Gene & Cell Therapy Terms and Conditions

Figure 1 Adenoviral genome size affects virion stability. (a) A schematic representation of adenovirus (Ad) virion structure based on cryoelectron microscopy and crystallography. (Reprinted from ref. 1 with permission of W.C. Russell and the Society for General Microbiology. (b) Heat stability of Ad virions is significantly impacted by the size of the packaged genome. Ad virions ranging in size from 30.2 to 36 kb were incubated at 47 °C for 0, 15, or 30 minutes and the residual virus titer was determined by standard plaque assay. (Adapted from ref. 22.) GFP, green fluorescent protein; WT, wild type. Molecular Therapy 2009 17, 1664-1666DOI: (10.1038/mt.2009.202) Copyright © 2009 The American Society of Gene & Cell Therapy Terms and Conditions