Recurrent Clostridium Difficile Seema Maroo, J. Thomas Lamont  Gastroenterology  Volume 130, Issue 4, Pages 1311-1316 (April 2006) DOI: 10.1053/j.gastro.2006.02.044 Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 1 Serum IgG anti-toxin A antibody response and clinical outcome. Serum IgG anti-toxin A antibody concentrations were measured prospectively in hospitalized patients with C difficile infection. A correlation between IgG response and the clinical outcome of infection was observed. Asymptomatic carriers mounted an early anamnestic response to toxin A. In contrast no significant increase in serum IgG antitoxin was found in patients with recurrent C difficile diarrhea. In those who had a single episode of diarrhea, anti-toxin A IgG was generally increased on day 12 of their first episode. This indicates that a serum antibody response to toxin A during C difficile infection is associated with protection against symptoms or against recurrent diarrhea. (Reprinted by permission from Warny M, Kelly C. Pathogenicity of Clostridium difficile toxins. In: G Hecht, ed. Microbial pathogensis and the intestinal epithelial cell. ASM Press. Washington, DC, 2003:503–524.) Gastroenterology 2006 130, 1311-1316DOI: (10.1053/j.gastro.2006.02.044) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions