Changes in Streptococcus pneumoniae serotypes causing invasive disease with non- universal vaccination coverage of the seven-valent conjugate vaccine 

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Changes in Streptococcus pneumoniae serotypes causing invasive disease with non- universal vaccination coverage of the seven-valent conjugate vaccine  S.I. Aguiar, I. Serrano, F.R. Pinto, J. Melo-Cristino, M. Ramirez  Clinical Microbiology and Infection  Volume 14, Issue 9, Pages 835-843 (September 2008) DOI: 10.1111/j.1469-0691.2008.02031.x Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Cases of invasive pneumococcal disease according to serotype and age group in Portugal (2003–2005). PCV7 indicates the serotypes included in the seven-valent conjugate vaccine. 13Pv indicates the serotypes included in the 13-valent conjugate vaccine currently under development. Clinical Microbiology and Infection 2008 14, 835-843DOI: (10.1111/j.1469-0691.2008.02031.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Changes in serotype distribution (1999–2005). Minima in mutual information graphs indicate the years dividing the study into two periods with maximally divergent serotype distributions. (a) Analysis concerning children ≤5 years of age. (b) Analysis concerning adults (≥18 years of age). Clinical Microbiology and Infection 2008 14, 835-843DOI: (10.1111/j.1469-0691.2008.02031.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions