René Ecochard, M. D. Ph. D. , Agnes Guillerm, M. D. , René Leiva, M. D

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Presentation transcript:

Characterization of follicle stimulating hormone profiles in normal ovulating women René Ecochard, M.D. Ph.D., Agnes Guillerm, M.D., René Leiva, M.D. Ph.D., Thomas Bouchard, M.D., Ana Direito, M.D., Hans Boehringer, Ph.D. Fertility and Sterility Volume 102, Issue 1, Pages 237-243.e5 (July 2014) DOI: 10.1016/j.fertnstert.2014.03.034 Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Number of days between the ultrasound-determined day of ovulation (US-DO) and the midcycle FSH peak. Fertility and Sterility 2014 102, 237-243.e5DOI: (10.1016/j.fertnstert.2014.03.034) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Examples of cycles with (A) typical, (B) low and flat, (C) increasing and irregular, and (D) low and irregular FSH during the follicular phase. Two examples of delayed ovulation: (E) after a first unsuccessful attempt, and (F) at the end of 4-day-long LH surge (data not shown). The day of ovulation day as determined by ultrasound is indicated by a circle. Fertility and Sterility 2014 102, 237-243.e5DOI: (10.1016/j.fertnstert.2014.03.034) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Averages of FSH profiles according to FSH trend during the follicular phase: (A) increasing level of FSH, (C) stable level of FSH, and (E) decreasing level of FSH. (B, D, F) Examples of each category. All of these cycles were confirmed to be ovulatory. Fertility and Sterility 2014 102, 237-243.e5DOI: (10.1016/j.fertnstert.2014.03.034) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Average of FSH profiles according to FSH stability during the follicular phase: (A) day-to-day stability of FSH, (C) low day-to-day variability of FSH, and (E) high day-to-day variability of FSH. (B, D, F) Examples of each category. All of these cycles were confirmed to be ovulatory. Fertility and Sterility 2014 102, 237-243.e5DOI: (10.1016/j.fertnstert.2014.03.034) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Flow diagram showing inclusion and exclusion characteristics of woman and cycles. Fertility and Sterility 2014 102, 237-243.e5DOI: (10.1016/j.fertnstert.2014.03.034) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Averages of FSH and LH profiles over 283 cycles. The dots and the dashed lines joining them represent the mean, and the vertical segments represent the SEM. Fertility and Sterility 2014 102, 237-243.e5DOI: (10.1016/j.fertnstert.2014.03.034) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 Transition between two successive cycles: average of FSH profiles according to the day of early follicular phase FSH peak profile. The cycles were classified into three terciles: (A) occurrence of the FSH peak very early, before day 2; (C) day 2 or day 3; and (E) day 4 or later. (B, D, F) Examples of each category. Fertility and Sterility 2014 102, 237-243.e5DOI: (10.1016/j.fertnstert.2014.03.034) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions