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Volume 68, Issue 1, Pages 391-398 (July 2005) Can murine diabetic nephropathy be separated from superimposed acute renal failure? Yuet-Ching Tay, Yiping Wang, Lukas Kairaitis, Gopala K. Rangan, Chun Zhang, David C.H. Harris Kidney International Volume 68, Issue 1, Pages 391-398 (July 2005) DOI: 10.1111/j.1523-1755.2005.00405.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Comparison of histologic changes in periodic acid-Schiff (PAS)-stained renal cortical sections from BALB/c mice (A to D and F) and C57BL/6J mice (E). (A) Without any injection. (B to D) with a single high dose of streptozotocin (STZ) (225mg/kg intraperitoneally, (F) with two low doses of STZ (75mg, 150mg/kg intravenously, and (E) with a single high dose of STZ (200mg/kg) intravenously. Diabetic animals maintained at normoglycemia were sacrificed at week 2 (D), while those maintained at hyperglycemia were sacrificed at week 1 (B) and week 2 (C, E, and F). The arrowed tubules in (B to E) show denudation of the epithelial cells consistent with acute tubular necrosis (ATN). Arrowheads (F) denote interstitial cell infiltrates (magnification 400×). Kidney International 2005 68, 391-398DOI: (10.1111/j.1523-1755.2005.00405.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Urinary glucose, μmol/16 hours (A), serum creatinine, μmol/L (B), creatinine clearance, mL/minute (C), for normal and diabetic BALB/c mice (regimen B, 75mg, 150mg/kg streptozocin (STZ) intravenously sacrificed at weeks (w) 1, 2, 4, and 8 post-STZ. Values are expressed as mean ± SD. *P <.05; **P < 0.001 when compared to normal animals. Kidney International 2005 68, 391-398DOI: (10.1111/j.1523-1755.2005.00405.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Comparison of histologic changes in periodic acid-Schiff (PAS)-stained renal sections from BALB/c mice (A) without any injection, (B and C) injected with two low doses of streptozotocin (STZ) (75mg, 150mg/kg intravenously). Diabetic mice were maintained at hyperglycemia. Arrows denote interstitial cell infiltrates at week 2 (B) and glomerulosclerosis at week 8 (C) (magnification 400×). Kidney International 2005 68, 391-398DOI: (10.1111/j.1523-1755.2005.00405.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 4 Morphometric analysis of normal and diabetic BALB/c mice sacrificed at weeks (w) 1, 2, 4 and 8 after induction of diabetes with 75mg, 150mg/kg streptozotocin (STZ). Diabetic mice were maintained at hyperglycemia prior to sacrifice. (A) Cortical tubular cell height, μm. (B) Glomerular area, μm2. (C) Glomerulosclerosis index [% of periodic acid-Schiff (PAS) material in tuft]. (D) Interstitial area (% of cortex). Values are expressed as mean ± SD. *P < 0.05; **P < 0.005. Kidney International 2005 68, 391-398DOI: (10.1111/j.1523-1755.2005.00405.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 5 Stained renal cryosections from BALB/c mice, sacrificed at week 2, (A, C, and E) without any injection; (B, D, and F) with two low doses of streptozotocin (STZ) (75mg, 150mg/kg intravenously) and maintained at hyperglycemia. (A and B) Stained for CD4. (C and D) Stained for CD8. (E and F) Stained for macrophage. Arrows denote respective cell surface markers (magnification 400×). Kidney International 2005 68, 391-398DOI: (10.1111/j.1523-1755.2005.00405.x) Copyright © 2005 International Society of Nephrology Terms and Conditions