The ascomycin macrolactam pimecrolimus (Elidel, SDZ ASM 981) is a potent inhibitor of mediator release from human dermal mast cells and peripheral blood.

Slides:

Advertisements

Similar presentations

Superior biologic activity of the recombinant bee venom allergen hyaluronidase expressed in baculovirus-infected insect cells as compared with Escherichia.

Advertisements

Reducing relative humidity to control the house dust mite Dermatophagoides farinae Larry G. Arlian, PhD, Jacqueline S. Neal, BS, DiAnn L. Vyszenski-Moher,

Assessment of inflammation in noninfectious chronic maxillary sinusitis Pascal Demoly, MDa, Louis Crampette, MDb, Michel Mondain, MDb, Alison M. Campbell,

W.Travis Cain, MDa, Greg Cable, PhDb, John J. Oppenheimer, MDc

Catherine M. Counsell, MAa, Julian F. Bond, PhDa, John L

Response to cyclosporin and low-dose methylprednisolone in aggressive systemic mastocytosis Motohiro Kurosawa, MD, PhD, PharmDa, Hiroo Amano, MD, PhDb,

The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,

Eosinophil cationic protein and histamine after intestinal challenge in patients with cow's milk intolerance Ulf Bengtsson, MD, PhDa, Tina W. Knutson,

Catherine M. Counsell, MAa, Julian F. Bond, PhDa, John L

Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine Amato de Paulis,

Asthma and increased bronchial responsiveness in elite athletes: Atopy and sport event as risk factors Ilkka J. Helenius, MDa, Heikki O. Tikkanen, MDb,

Elevated circulating adenosine level potentiates antigen-induced immediate bronchospasm and bronchoconstrictor mediator release in sensitized guinea pigs

Practice Notes from the AAAI

Badrul A. Chowdhury, MD, PhD

Inflammation of small airways in asthma

Adverse effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors associated with elevated serum IgE and eosinophilia Carol K. Fosso, MDa,

Clinical pharmacology of H1-antihistamines in the skin

Elephantiasis nostras: A case report

Cristiana Stellato, MD, PhDa, Jun Atsuta, MD, PhDb, Carol A

Involvement of ion channels in human eosinophil respiratory burst

Anaphylactic reaction to local administration of rifamycin SV

Practice Notes from the AAAAI

Yanli Ouyang, MD, PhDa, Nisha Virasch, BSa, Ping Hao, MDa, Michael T

Increased sensitivity to bradykinin among African Americans

The effects of glucocorticoids on human eosinophils

News & Notes Journal of Allergy and Clinical Immunology

Correlation between alcohol-induced asthma and acetaldehyde dehydrogenase-2 genotype Atsuko Takao, MDa, Terufumi Shimoda, MDa, Shigeru Kohno, MDa, Sadahiro.

Interactions between monocytes and smooth-muscle cells can lead to extracellular matrix degradation Yun Kui Zhu, MDa, Xiangde Liu, MDb, Hangjun Wang,

The immunopharmacology of mild asthma

Selective allergic reactions to clavulanic acid

Inflammatory cells, cytokine and chemokine expression in asthma immunocytochemistry and in situ hybridization Qutayba Hamid, MD, PhD, Editor Journal.

Barbara Foster, MSa, Lawrence B

IgE in unselected like-sexed monozygotic and dizygotic twins at birth and at 6 to 9 years of age: High but dissimilar genetic influence on IgE levels

Subjective and objective assessments in patients with seasonal allergic rhinitis: Effects of therapy with mometasone furoate nasal spray Eli O. Meltzer,

Molecular virology and immunology of HIV infection

New concepts: The basophil

Classification of anti-FcϵRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity Ruth A. Sabroe, MDa, Edda.

News & Notes Journal of Allergy and Clinical Immunology

IL-9 expression by human eosinophils: Regulation by IL-1β and TNF-α

No correlation between wine intolerance and histamine content of wine

Quantitation of H1-receptor antagonists in skin and serum

F. Estelle R. Simons, MD, FRCPCa, Xiaochen Gu, PhDb, Keith J

Case report: Streptomycin-induced anaphylactic shock during oocyte retrieval procedures for in vitro fertilization Motoyasu Iikura, MD, PhDa, Masao Yamaguchi,

Assessment of inflammation in noninfectious chronic maxillary sinusitis Pascal Demoly, MDa, Louis Crampette, MDb, Michel Mondain, MDb, Alison M. Campbell,

Histamine and tryptase levels in patients with acute allergic reactions: An emergency department–based study Robert Y. Lin, MDa, Lawrence B. Schwartz,

The 30th anniversary of the American Board of Allergy and Immunology: Then and now Lynn Des Prez a, Charles E. Reed, MD, Lawrence B. Schwartz, MDb, John.

Loratadine reduces allergen-induced mucosal output of α2-macroglobulin and tryptase in allergic rhinitis Lennart Greiff, MD, PhDa, Carl G.A. Persson,

Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects Neil E. Alexis,

The role and remediation of animal allergens in allergic diseases

Chemokines in seasonal allergic rhinitis

Larry L. Thomas, PhD, Michelle D. Haskell, Emmanuel U

Phosphorylation of cytosolic phospholipase A2 by IL-3 is associated with increased free arachidonic acid generation and leukotriene C4 release in human.

Preparing patients and health professionals for the transition to chlorofluorocarbon-free inhalers: The British perspective Helen Donohoe, MSc (Econ)

Practice Notes from the AAAI

Induced sputum: Validity of fluid-phase IL-5 measurement

13-Hydroxy-linoleic acid induces airway hyperresponsiveness to histamine and methacholine in guinea pigs in vivo Paul A.J. Henricks, PhDa, Ferdi Engels,

Anaphylaxis after initial ingestion of rambutan, a tropical fruit

Proteinase-activated receptor-2–mediated matrix metalloproteinase-9 release from airway epithelial cells Harissios Vliagoftis, MDa, Andreas Schwingshackl,

Food allergen (peanut)–specific T H2 clones generated from the peripheral blood of a patient with peanut allergy Esther C. de Jong, MSca, b, Steven Spanhaak,

Abnormalities of cell and mediator levels in bronchoalveolar lavage fluid of patients with mild asthma Sally E. Wenzel, MD Journal of Allergy and Clinical.

Dexamethasone suppresses gene expression and production of IL-13 by human mast cell line and lung mast cells Toshiaki Fushimi, MD, Hiroshi Okayama, MD,

IL-4 upregulates FcϵRI α-chain messenger RNA in eosinophils

Footnotes1 Journal of Allergy and Clinical Immunology

Evelyn Farinas, RPh, MGA, Peter Honig, MD

Differences in proliferation of the hematopoietic cell line TF-1 and cytokine production by peripheral blood leukocytes induced by 2 naturally occurring.

News & Notes Journal of Allergy and Clinical Immunology

Histamine release in intact human skin by monocyte chemoattractant factor-1, RANTES, macrophage inflammatory protein-1α, stem cell factor, anti-IgE, and.

Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase–dependent manner Tetsuya Adachi, MDa, Susan Stafford,

Advances in mechanisms of allergic disease in 2016

Pascal Chanez, MDa, Antonio M

Presentation transcript:

The ascomycin macrolactam pimecrolimus (Elidel, SDZ ASM 981) is a potent inhibitor of mediator release from human dermal mast cells and peripheral blood basophils Torsten Zuberbier, MDa, Sie-Uen Chong, a, Karl Grunow, MDa, Sven Guhl, a, Pia Welker, PhDa, Maximilian Grassberger, PhDb, Beate M. Henz, MDa Journal of Allergy and Clinical Immunology Volume 108, Issue 2, Pages 275-280 (August 2001) DOI: 10.1067/mai.2001.116865 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 Anti-IgE–induced (2000 IU/mL) histamine release from human dermal mast cells preincubated with pimecrolimus (Pim ; mean ± SEM, n = 10, histamine release of controls = 13% ± 1.6% of total histamine, P < .01 for concentrations of ≥10 nmol/L pimecrolimus), cyclosporin A (CsA ), and dexamethasone (Dexa ; mean ± SEM; n = 3; histamine release of controls = 7.6% ± 1.5% of total histamine). Journal of Allergy and Clinical Immunology 2001 108, 275-280DOI: (10.1067/mai.2001.116865) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 Effect of the pimecrolimus (Pim ) antagonist rapamycin (RA ) on pimecrolimus during anti-IgE–induced (2000 IU/mL) histamine release (mean ± SEM; n = 5; histamine release of controls = 10.4% ± 1.9 of total histamine; P > .05). Journal of Allergy and Clinical Immunology 2001 108, 275-280DOI: (10.1067/mai.2001.116865) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 3 Dose-dependent effect of pimecrolimus (Pim ) on anti-IgE–induced (2000 IU/mL) tryptase release from dermal mast cells (mean ± SEM; n = 3). Journal of Allergy and Clinical Immunology 2001 108, 275-280DOI: (10.1067/mai.2001.116865) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 4 Dose-dependent influence of pimecrolimus (Pim ) and cyclosporin A (CsA ; 100 nmol/L) on anti-IgE–induced (2000 IU/mL) LTC4 release from dermal mast cells (mean ± SEM; n = 3; LTC4 release of controls = 63 ± 21 pg/mL). Journal of Allergy and Clinical Immunology 2001 108, 275-280DOI: (10.1067/mai.2001.116865) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 5 Dose-dependent effect of pimecrolimus (Pim ) on calcium ionophore A23187 (0.2 μmol/L) plus PMA–induced (20 ng/mL) TNF-α release from purified dermal mast cells (mean ± SEM; n = 4; TNF-α release of controls = 508 ± 134 pg/mL). Journal of Allergy and Clinical Immunology 2001 108, 275-280DOI: (10.1067/mai.2001.116865) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 6 Dose-dependent effect of pimecrolimus (Pim ) on anti-IgE–induced (200 IU/mL) histamine release from human basophils (mean ± SEM; n = 3; histamine release of controls = 28.3% ± 5.4% of total histamine). Journal of Allergy and Clinical Immunology 2001 108, 275-280DOI: (10.1067/mai.2001.116865) Copyright © 2001 Mosby, Inc. Terms and Conditions