Inflammatory response to cardiac bypass in ewe fetuses: effects of steroid administration or continuous hemodiafiltration Adriano Carotti, MD, Francesco.

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Presentation transcript:

Inflammatory response to cardiac bypass in ewe fetuses: effects of steroid administration or continuous hemodiafiltration Adriano Carotti, MD, Francesco Emma, MD, Stefano Picca, MD, Enrico Iannace, MD, Sonia B Albanese, MD, Mauro Grigioni, MS, Francesco Meo, PhD, Mario Sciarra, PhD, Roberto M Di Donato, MD The Journal of Thoracic and Cardiovascular Surgery Volume 126, Issue 6, Pages 1839-1848 (December 2003) DOI: 10.1016/S0022-5223(03)01293-5

Figure 1 Fetal arterial blood gas trends expressed as means ± SE. Open circles, control animals; filled circles, treatment groups; shaded area, CB; O2 Sat, arterial oxygen saturation. *P < .05 (Mann-Whitney U test). The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1839-1848DOI: (10.1016/S0022-5223(03)01293-5)

Figure 2 Fetal hemodynamic and biochemical trends expressed as means ± SE. Open circles, control animals; filled circles, treatment groups; shaded area, CB; HR, heart rate; SBP, systolic arterial blood pressure; glucose, glucose blood level; lactate, lactate blood level. *P < .05 (Mann-Whitney U test). The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1839-1848DOI: (10.1016/S0022-5223(03)01293-5)

Figure 3 Fetal trends of plasma levels of vasoactive peptides expressed as means ± SE. Open circles, control animals; filled circles, treatment groups; shaded area, CB; ET, endothelin. *P < .05 (Mann-Whitney U test). The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1839-1848DOI: (10.1016/S0022-5223(03)01293-5)

Figure 4 Performance score analysis that cumulates metabolic and hemodynamic data from 7 different parameters, including arterial pH, Paco2 (millimeters of mercury), HCO3− (millimoles per liter), arterial oxygen saturation (percentage), lactate blood level (millimoles per liter), systolic arterial blood pressure (millimeters of mercury), and diastolic arterial blood pressure (millimeters of mercury). Open circles, control animals; triangles, maternal pretreatment with betamethasone; inverted triangles, fetal treatment with methylprednisolone; filled squares, fetal CVVHD. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1839-1848DOI: (10.1016/S0022-5223(03)01293-5)