Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass

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Presentation transcript:

Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass Christine S. Rinder, MDa, Dorothy Gaal, MDa, Laura A. Student, BSb, Brian R. Smith, MDb The Journal of Thoracic and Cardiovascular Surgery Volume 107, Issue 1, Pages 280-288 (January 1994) DOI: 10.5555/uri:pii:S0022522394704821 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 Changes in surface expression of platelet GPIb. Mean fluorescence of anti-GPIb antibody binding to platelets was measured in samples of whole blood taken before start of operation (BASE), 5 minutes after heparinization (HEPARIN), 10 minutes after start of operation (10 MIN CPB), shortly before separation from CPB (END CPB), and 1 to 2 hours after termination of CPB (1H POST CPB). Values are shown as mean ± 1standard deviation. Noncyanotic patients are represented by black circles, cyanotic patients by black diamonds, and mean for all patients by open squares. GBIb decreased significantly at end of CPB and 1 to 2 hours after CPB compared with baseline values. In addition, surface expression of GPIb in cyanotic patients was significantly lower than that in noncyanotic patients (p = 0.01) for all time points. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 280-288DOI: (10.5555/uri:pii:S0022522394704821) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 Platelet activation with CPB. Percentage of circulating platelets expressing P-selectin was measured at time points described in Fig. 1. All values represent means ± Standard error of themean for the 13 patients. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 280-288DOI: (10.5555/uri:pii:S0022522394704821) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 Leukocyte-platelet conjugates with CPB. Percentage of leukocyte-platelet conjugates was measured in whole blood taken at time points described in Fig. 1. All values represent means ± Standard error of the mean for the 13 patients. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 280-288DOI: (10.5555/uri:pii:S0022522394704821) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 Leukocyte CD11b with CPB. Fluorescence-labeling of CD11b was measured on monocytes and PMN in whole blood taken at time points described in Fig. 1 and are expressed as percentage of baseline fluorescence value. Each measurement is shown as mean ± standard error of the mean for the 13 patients. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 280-288DOI: (10.5555/uri:pii:S0022522394704821) Copyright © 1994 Mosby, Inc. Terms and Conditions