Cost-effectiveness of Xpert MTB/RIF for tuberculosis diagnosis in South Africa: a real- world cost analysis and economic evaluation Prof Anna Vassall,

Slides:

Advertisements

Similar presentations

Catastrophic costs potentially averted by tuberculosis control in India and South Africa: a modelling study Dr Stéphane Verguet, PhD, Carlos Riumallo-Herl,

Advertisements

Food systems, nutrition, health and the environment

Effect of a bereavement support group on female adolescents' psychological health: a randomised controlled trial in South Africa Prof Tonya Renee Thurman,

Authorship trends in The Lancet Global Health

The commercial determinants of health

Helen Cox, Mark P Nicol The Lancet Infectious Diseases

The impact of megacities on health: preparing for a resilient future

Assessment of progress towards universal health coverage for people with disabilities in Afghanistan: a multilevel analysis of repeated cross-sectional.

Charity begins at home in global health research funding

Threats to human health by great ocean garbage patches

Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: a cluster-randomised trial embedded in South African roll-out.

Prevalence of cerebral palsy in Uganda: a population-based study

Do air quality alerts benefit public health? New evidence from Canada

Global, regional, and subregional trends in unintended pregnancy and its outcomes from 1990 to 2014: estimates from a Bayesian hierarchical model Jonathan.

The Lancet Global Health

Gender myths in global health

Nicola Low, Joost H Smid The Lancet Public Health

Effective cross-sector collaborations create sustainability

Prevention of suicide with regulations aimed at restricting access to highly hazardous pesticides: a systematic review of the international evidence

Socioeconomic differences in mortality in the antiretroviral therapy era in Agincourt, rural South Africa, 2001–13: a population surveillance analysis

The effect of explosive remnants of war on global public health: a systematic mixed- studies review using narrative synthesis Alexandra Frost, MSc, Prof.

National, regional, and global prevalence of smoking during pregnancy in the general population: a systematic review and meta-analysis Shannon Lange,

Arnaud Chiolero The Lancet Public Health

Jonathan Broad, Matthew D Snape The Lancet Public Health

Malebona Precious Matsoso, Jeanette Rebecca Hunter, Vishal Brijlal

Food systems, nutrition, health and the environment

Socioeconomic differences in mortality in the antiretroviral therapy era in Agincourt, rural South Africa, 2001–13: a population surveillance analysis

Sherif M Abdalla, Robert Bortolussi, Noni E MacDonald

Improving completeness of birth and death registration in rural Africa

The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis Prof Karen Hughes, PhD, Prof Mark A Bellis, DSc,

Measuring health and economic wellbeing in the Sustainable Development Goals era: development of a poverty-free life expectancy metric and estimates for.

Comparison of sputum collection methods for tuberculosis diagnosis: a systematic review and pairwise and network meta-analysis Dr Sumona Datta, MD, Lena.

Trends in infant mortality in Venezuela between 1985 and 2016: a systematic analysis of demographic data Jenny García, MSc, Prof Gerardo Correa, MSc,

Authorship trends in The Lancet Global Health

Risk of poor development in young children in low-income and middle-income countries: an estimation and analysis at the global, regional, and country.

Effect of a bereavement support group on female adolescents' psychological health: a randomised controlled trial in South Africa Prof Tonya Renee Thurman,

Cost-effectiveness of community-based screening and treatment for chronic hepatitis B in The Gambia: an economic modelling analysis Dr Shevanthi Nayagam,

Fatal and non-fatal injury outcomes: results from a purposively sampled census of seven rural subdistricts in Bangladesh Dr Olakunle Alonge, PhD, Priyanka.

Elder abuse prevalence in community settings: a systematic review and meta-analysis Yongjie Yon, MA, Christopher R Mikton, PhD, Zachary D Gassoumis, PhD,

Sufang Guo, Nuzhat Rafique, Danzhen You, Douglas J Noble

Forecasting the care needs of the older population in England over the next 20 years: estimates from the Population Ageing and Care Simulation (PACSim)

Anna J Dare, Calvin Ke, Wilson Suraweera, Peter Rodriguez, Prabhat Jha

Cost-effectiveness of urine-based tuberculosis screening in hospitalised patients with HIV in Africa: a microsimulation modelling study Krishna P Reddy,

Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis Gian Luca Di Tanna, PhD, Ali Raza Khaki,

Cost-effectiveness of HIV prevention for high-risk groups at scale: an economic evaluation of the Avahan programme in south India Dr Anna Vassall, PhD,

Thank you to our diverse (but not diverse enough) reviewers

Rapid diagnosis of pulmonary tuberculosis in African children in a primary care setting by use of Xpert MTB/RIF on respiratory specimens: a prospective.

Matthieu J Guitton The Lancet Planetary Health

Fatal and non-fatal injury outcomes: results from a purposively sampled census of seven rural subdistricts in Bangladesh Dr Olakunle Alonge, PhD, Priyanka.

Household contact investigation for the detection of tuberculosis in Vietnam: economic evaluation of a cluster-randomised trial Thomas Lung, PhD, Guy.

Assessment of the patient, health system, and population effects of Xpert MTB/RIF and alternative diagnostics for tuberculosis in Tanzania: an integrated.

Spatial lifecourse epidemiology

Effectiveness of strategies to improve health-care provider practices in low-income and middle-income countries: a systematic review Alexander K Rowe,

Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation

Restructuring physical micro-environments to reduce the demand for meat: a systematic review and qualitative comparative analysis Filippo Bianchi, MPhil,

Jean H Humphrey, Andrew J Prendergast The Lancet Global Health

Sustaining pneumococcal vaccination after transitioning from Gavi support: a modelling and cost-effectiveness study in Kenya John Ojal, PhD, Ulla Griffiths,

Reducing the cardiovascular disease burden for people of all ages in the Americas region: analysis of mortality data, 2000–15 Prof Peter Lloyd-Sherlock,

Improving management of neonatal infections

Population attributable fractions for risk factors for dementia in low-income and middle- income countries: an analysis using cross-sectional survey data

Deriving a practical framework for the evaluation of health apps

Excess under-5 female mortality across India: a spatial analysis using 2011 census data Christophe Z Guilmoto, PhD, Nandita Saikia, PhD, Vandana Tamrakar,

Refining treatment choices for ADHD

Use of standardised patients to assess gender differences in quality of tuberculosis care in urban India: a two-city, cross-sectional study Benjamin.

Lauri Romanzi, John G Meara, Erin Anastasi, Anneka T Knutsson

The escalating global burden of serious health-related suffering: projections to 2060 by world regions, age groups, and health conditions Katherine E.

Effect of strikes by health workers on mortality between 2010 and 2016 in Kilifi, Kenya: a population-based cohort analysis Gerald Ong'ayo, MBChB, Michael.

Institutional challenges to achieving health equity in Ecuador

Sickle cell disease: a new era

Fixed-combination, low-dose, triple-pill antihypertensive medication versus usual care in patients with mild-to-moderate hypertension in Sri Lanka: a.

Presentation transcript:

Cost-effectiveness of Xpert MTB/RIF for tuberculosis diagnosis in South Africa: a real- world cost analysis and economic evaluation Prof Anna Vassall, PhD, Mariana Siapka, MSc, Nicola Foster, MSc, Lucy Cunnama, MSc, Lebogang Ramma, MSc, Prof Katherine Fielding, PhD, Kerrigan McCarthy, MSc, Prof Gavin Churchyard, PhD, Prof Alison Grant, PhD, Edina Sinanovic, PhD The Lancet Global Health Volume 5, Issue 7, Pages e710-e719 (July 2017) DOI: 10.1016/S2214-109X(17)30205-X Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Cost-effectiveness planes of Xpert versus sputum smear microscopy Cost-effectivness planes showing the results of two different models of non-parametric two-stage bootstrapping using 10 000 replications to produce incremental costs per DALYs averted for Xpert versus sputum smear microscopy, with 3% (A) and 0% (B) discount rates. The x-axis represents the difference in DALYs averted, and the y-axis represents the difference in costs for the imputed data using 10 000 replications. Each point in the scatterplot represents one bootstrap iteration. Costs are in 2014 US$. DALY=disability-adjusted life-year. The Lancet Global Health 2017 5, e710-e719DOI: (10.1016/S2214-109X(17)30205-X) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Cost-effectiveness acceptability curves of Xpert versus sputum smear microscopy The cost-effectiveness acceptability curves were generated by running 10 000 replications. The probability of Xpert being cost-effective was examined at different WTP thresholds, with 3% (A) and 0% (B) discount rates. Costs are in 2014 US$. WTP=willingness to pay. DALY=disability-adjusted life-year. The Lancet Global Health 2017 5, e710-e719DOI: (10.1016/S2214-109X(17)30205-X) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions