Volume 148, Issue 3, Pages e4 (March 2015)

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Volume 148, Issue 3, Pages 537-546.e4 (March 2015) Quantitative Gastrointestinal and Psychological Traits Associated With Obesity and Response to Weight-Loss Therapy  Andres Acosta, Michael Camilleri, Andrea Shin, Maria I. Vazquez-Roque, Johanna Iturrino, Duane Burton, Jessica O’Neill, Deborah Eckert, Alan R. Zinsmeister  Gastroenterology  Volume 148, Issue 3, Pages 537-546.e4 (March 2015) DOI: 10.1053/j.gastro.2014.11.020 Copyright © 2015 AGA Institute Terms and Conditions

Figure 1 Upper panel: Relationship of kilocalorie intake at prior ad libitum meal and kilocalorie intake in response to randomized treatment; note that there are significant associations in both treatment groups. Lower panel: Association of change in body weight (in response to randomized treatment with placebo or phentermine-topiramate-ER) and kilocalorie intake at prior ad libitum meal. Note the kilocalorie intake at baseline before treatment is associated with the degree of weight loss on treatment with phentermine-topiramate-ER with no observed effect with placebo treatment. This is illustrated by P = .029 for the drug treatment interaction. Gastroenterology 2015 148, 537-546.e4DOI: (10.1053/j.gastro.2014.11.020) Copyright © 2015 AGA Institute Terms and Conditions

Supplementary Figure 1 CONSORT (Consolidated Standards of Reporting Trials) flow chart for randomized controlled trial of effects of phentermine-topiramate-ER on weight loss and quantitative traits in obesity. Gastroenterology 2015 148, 537-546.e4DOI: (10.1053/j.gastro.2014.11.020) Copyright © 2015 AGA Institute Terms and Conditions

Supplementary Figure 2 Study protocol for randomized controlled trial of effects of phentermine-topiramate-ER on weight loss and quantitative traits measured on days 12 to 14 of treatment. Gastroenterology 2015 148, 537-546.e4DOI: (10.1053/j.gastro.2014.11.020) Copyright © 2015 AGA Institute Terms and Conditions