Volume 378, Issue 9809, Pages 2104-2111 (December 2011) Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial  Dr Padraig Warde, MB, Malcolm Mason, MB, Keyue Ding, PhD, Peter Kirkbride, MB, Michael Brundage, MD, Richard Cowan, MB, Mary Gospodarowicz, MD, Karen Sanders, BSc, Edmund Kostashuk, MD, Greg Swanson, MD, Jim Barber, MB, Andrea Hiltz, MSc, Mahesh KB Parmar, PhD, Jinka Sathya, MB, John Anderson, MB, Charles Hayter, MD, John Hetherington, MB, Matthew R Sydes, CStat, Wendy Parulekar, MD  The Lancet  Volume 378, Issue 9809, Pages 2104-2111 (December 2011) DOI: 10.1016/S0140-6736(11)61095-7 Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile ADT=androgen deprivation therapy. RT=radiation therapy. The Lancet 2011 378, 2104-2111DOI: (10.1016/S0140-6736(11)61095-7) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 2 Overall and disease-specific survival at 7 years (A) Kaplan-Meier curve for overall survival by treatment group. (B) Kaplan-Meier curve for disease-specific survival by treatment group, and (C) cumulative incidence of disease-specific survival. ADT=androgen deprivation therapy. RT=radiation therapy. The Lancet 2011 378, 2104-2111DOI: (10.1016/S0140-6736(11)61095-7) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 3 Mean quality-of-life scores over time for symptom measures. A high mean score represents a high symptom burden. ADT=androgen deprivation therapy. EORTC=European Organisation for Research and Treatment of Cancer. FACT-P=Functional Assessment of Cancer Therapy–Prostate. The Lancet 2011 378, 2104-2111DOI: (10.1016/S0140-6736(11)61095-7) Copyright © 2011 Elsevier Ltd Terms and Conditions