Gourisankar Ghosh, Malini Sen Molecular Cell

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A New DNA Methyltransferase-Histone Deacetylase-Kinase Axis in Innate Immunity Gourisankar Ghosh, Malini Sen Molecular Cell Volume 63, Issue 4, Pages 544-546 (August 2016) DOI: 10.1016/j.molcel.2016.08.007 Copyright © 2016 Terms and Conditions

Figure 1 DNA Methylation and Kinase Acetylation in Innate Immunity (Left) A cartoon depicting DNMT3a recruitment, promoter methylation, and gene expression regulation. Via Repression of a class of gene dependent on promoter methylation, DNMT3a is recruited to the promoter by unmethylated Histone H3K4. The mechanism by which DNMT3a is recruited to the promoters of activated gene such as HDAC9 is unknown. (Right) Overlay of two TBK1 structures (PDB ID: 4EUU [cyan] and 4IWO [gray]) showing different conformational variations of Lys241. Conformations of Lys241 are not correlated to Ser172 phosphorylation or AL conformation. Molecular Cell 2016 63, 544-546DOI: (10.1016/j.molcel.2016.08.007) Copyright © 2016 Terms and Conditions