Translational Control: Awakening dormant mRNAs

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Translational Control: Awakening dormant mRNAs J.-D. Vassalli, A. Stutz  Current Biology  Volume 5, Issue 5, Pages 476-479 (May 1995) DOI: 10.1016/S0960-9822(95)00095-9

Figure 1 Multiple roles for mRNA 3′UTRs. Sequence elements in the 3′UTR of different mRNAs are involved in controlling aspects of the fate of the mRNA itself, such as its subcellular localization (illustrated by the distribution of bicoid mRNA in Drosophila eggs), its association with polysomes (and thereby its translation), its state of polyadenylation (which controls its translation in oocytes and eggs) and its rate of decay The 3′ UTR elements can control the different fates of mRNA either positively — for example, polyadenylation induces recruitment on polysomes — or negatively — for example, UA-rich elements arrest translation of injected mRNAs in Xenopus eggs. Current Biology 1995 5, 476-479DOI: (10.1016/S0960-9822(95)00095-9)