Volume 141, Issue 5, Pages 1593-1604 (November 2011) An Antibody Against IL-5 Reduces Numbers of Esophageal Intraepithelial Eosinophils in Children With Eosinophilic Esophagitis  Amal H. Assa'ad, Sandeep K. Gupta, Margaret H. Collins, Mike Thomson, Amy T. Heath, Deborah A. Smith, Teresa L. Perschy, Cynthia H. Jurgensen, Hector G. Ortega, Seema S. Aceves  Gastroenterology  Volume 141, Issue 5, Pages 1593-1604 (November 2011) DOI: 10.1053/j.gastro.2011.07.044 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 Study timeline and enrollment and follow-up of patients. (A) Study timeline. (B) Numbers of patients screened, randomized, and providing response to therapy data. Gastroenterology 2011 141, 1593-1604DOI: (10.1053/j.gastro.2011.07.044) Copyright © 2011 AGA Institute Terms and Conditions

Figure 2 Esophageal intraepithelial eosinophil counts at baseline (n = 59) and response to therapy at week 12 (n = 57) and at the end of follow-up at week 24 (n = 54). (A) Mean and SE (bars) of peak intraepithelial eosinophil counts per hpf by treatment group. Overall (line not shown), there was a significant decrease from baseline at week 12 (P <.0001) and a significant decrease from baseline at week 24 (P = .0002). (B) Mean and SE (bars) of mean eosinophil counts by treatment group. Overall (line not shown), there was a significant decrease from baseline at week 12 (P < .0001) and a significant decrease from baseline at week 24 (P < .0001). (C) Overall mean percent of hpfs with <5 or ≥20 eosinophils showing a significant increase from baseline at week 12 and week 24 (P ≤ .003) in the percent of hpfs with <5 eosinophils and a significant decrease from baseline at week 12 and week 24 (P ≤ .0006) in the percent of hpfs with ≥20 eosinophils. (D) Mean ± SD plasma concentration-time profile for mepolizumab. Gastroenterology 2011 141, 1593-1604DOI: (10.1053/j.gastro.2011.07.044) Copyright © 2011 AGA Institute Terms and Conditions