Risk Factors for Developing Postthymectomy Myasthenia Gravis in Thymoma Patients Yoshito Yamada, MD, PhD, Shigetoshi Yoshida, MD, PhD, Takekazu Iwata,

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Risk Factors for Developing Postthymectomy Myasthenia Gravis in Thymoma Patients Yoshito Yamada, MD, PhD, Shigetoshi Yoshida, MD, PhD, Takekazu Iwata, MD, PhD, Hidemi Suzuki, MD, PhD, Tetsuzo Tagawa, MD, PhD, Teruaki Mizobuchi, MD, PhD, Naoki Kawaguchi, MD, PhD, Ichiro Yoshino, MD, PhD The Annals of Thoracic Surgery Volume 99, Issue 3, Pages 1013-1019 (March 2015) DOI: 10.1016/j.athoracsur.2014.10.068 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Tree diagram of the thymoma patients in this study. The scheme shows patients categorized by preoperative (preop) and postoperative (postop) thymectomy myasthenia gravis (MG) and preoperative level of acetylcholine receptor antibody (AchR-Ab). (Minus symbol [−] = without MG; plus symbol [+] = with MG.) The Annals of Thoracic Surgery 2015 99, 1013-1019DOI: (10.1016/j.athoracsur.2014.10.068) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Kaplan-Meier curves for freedom from myasthenia gravis (MG) generated using (A) preoperative acetylcholine receptor antibodies (AchR-Ab) test results (dotted line = AchR-Ab < 0.2; solid line = AchR-Ab ≥ 0.2); (B) World Health Organization (WHO) histologic classification of thymoma (dotted line = type A/AB; solid line = type B1–3); and (C) completeness of resection (dotted line = complete [R0]; solid line = incomplete [R1, 2]). These three variables showed significant differences in log rank tests. The Annals of Thoracic Surgery 2015 99, 1013-1019DOI: (10.1016/j.athoracsur.2014.10.068) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Box plot showing that the acetylcholine receptor antibody (AchR-Ab) level at the onset of myasthenia gravis (MG) after thymectomy was significantly higher than the level before surgery (p = 0.036). Outliers are shown as asterisks. The Annals of Thoracic Surgery 2015 99, 1013-1019DOI: (10.1016/j.athoracsur.2014.10.068) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions