Nucleophagy: A New Look at Past Observations Han Peng, Robert M. Lavker  Journal of Investigative Dermatology  Volume 136, Issue 7, Pages 1316-1318 (July 2016) DOI: 10.1016/j.jid.2016.04.019 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Autophagy and its initiation. (a) Schematic representation of the stages of autophagy. (b) A schematic representation of the initial steps in autophagy involving the formation of an isolation membrane. In this process, unc-51 like autophagy activating kinase 1 (ULK1) complex activates the phosphatidylinositol-3-kinase (PI3K) complex (VPS34/Beclin1/ATG14L). VPS34-derived PI3P recruits double FYVE-containing protein 1 (DFCP1/ZFYVE1) and WD repeat domain phosphoinositide interacting 1 (WIPI1) to the outer membrane of autophagosomes, which causes the association of the ATG5/ATG12 conjugate with ATG16L1. The ATG5/ATG12/ATG16L1 complex then adds the phosphatidylethanolamine group (PE) to the C-terminus of the microtubule associated protein 1 light chain 3 (LC3) protein, promoting the elongation of the isolation membrane and autophagosome formation. Journal of Investigative Dermatology 2016 136, 1316-1318DOI: (10.1016/j.jid.2016.04.019) Copyright © 2016 The Authors Terms and Conditions