Volume 58, Issue 2, Pages (August 2000)

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Volume 58, Issue 2, Pages 629-637 (August 2000) Immunoglobulins in chronic renal failure of childhood: Effects of dialysis modalities Antonia H.M. Bouts, Jean-Claude Davin, Raymond T. Krediet, Mirjam B. Van Der Weel, Cornelis H. Schröder, Leo Monnens, Jeroen Nauta, Theo A. Out Kidney International Volume 58, Issue 2, Pages 629-637 (August 2000) DOI: 10.1046/j.1523-1755.2000.00209.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Total serum immunoglobulin G (IgG) and IgG2 in healthy children (HC) and in children on peritoneal dialysis (PD). The solid line marks the 25th percentile of normal values12,13. Kidney International 2000 58, 629-637DOI: (10.1046/j.1523-1755.2000.00209.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Relationship between peritoneal IgG clearance and the mass transfer area coefficient of creatinine (MTACCr) in children on peritoneal dialysis (PD). MTACCr was calculated according to the Waniewski method (r = 0.72, P = 0.0003, 95% CI, 0.4 to 0.9)19. Kidney International 2000 58, 629-637DOI: (10.1046/j.1523-1755.2000.00209.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Peritoneal IgG clearances in PD children with IgG1, IgG2, or no IgG subclass deficiency. The solid line marks the median values; *P = 0.025. Kidney International 2000 58, 629-637DOI: (10.1046/j.1523-1755.2000.00209.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 Serum IgG in relationship to the duration of PD treatment (*P = 0.003). Kidney International 2000 58, 629-637DOI: (10.1046/j.1523-1755.2000.00209.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 5 Albumin and total IgG concentration in serum and peritoneal dialysis effluent (PDE) in relationship to a peritonitis episode. Abbreviations are: NI, noninfectious state, that is,> 3 months before or after a peritonitis episode; P0, at the moment of peritonitis presentation; P14, 14 days after the initial presentation; P28, 28 days after the initial presentation. *P = 0.003; **P = 0.04; ***P = 0.008. Kidney International 2000 58, 629-637DOI: (10.1046/j.1523-1755.2000.00209.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 6 Peritonitis incidence defined as the number of episodes per patient year in children with normal serum IgG1 or IgG2 (normal Ig) or reduced IgG1 or IgG2 (reduced Ig) (<2.5 percentile of normal value). The line marks the median peritonitis incidence; it was 0.8 in the normal Ig group and 1.5 in the reduced Ig group. The difference between the groups was not significant (P = 0.13). Kidney International 2000 58, 629-637DOI: (10.1046/j.1523-1755.2000.00209.x) Copyright © 2000 International Society of Nephrology Terms and Conditions