ALT Telomeres Borrow from Meiosis to Get Moving

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ALT Telomeres Borrow from Meiosis to Get Moving Nausica Arnoult, Jan Karlseder Cell Volume 159, Issue 1, Pages 11-12 (September 2014) DOI: 10.1016/j.cell.2014.09.013 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Clustering of Telomeres in ALT Cells During alternative lengthening of telomeres (ALT), telomeres are maintained through a recombinogenic mechanism relying on a direct, long distance homology search facilitated by factors more typically linked to meiosis. Induction of damage at telomeres in ALT cells by Fok1-TRF1 expression leads to Rad51 recruitment. Subsequent association of Hop2-Mnd1 modifies Rad51 to promote the homology search. Rad51 filaments provide a backbone for directional movement and telomere clustering, thereby allowing recombination. Non-ALT cells lack this capacity. Cell 2014 159, 11-12DOI: (10.1016/j.cell.2014.09.013) Copyright © 2014 Elsevier Inc. Terms and Conditions