178 Ch/Ad CM cases (≤20 years) from M-SKIP database

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Presentation transcript:

178 Ch/Ad CM cases (≤20 years) from M-SKIP database 59 Ch/Ad excluded because the MC1R gene was not sequenced 308 Ch/Ad cases with MC1R information 75 Ch/Ad cases excluded because there was no histopathological report available 233 Ch/Ad CM cases included in the study For case-case analysis: 1:4 Ch/Ad case-A case matching from M-SKIP dataset (N=8582 adults) For case-control analysis: 1:4 Ch/Ad case-A unaffected controls matching from M-SKIP dataset (N=5770 adults) 189 Ch/Ad CM cases (≤20 years) from IMI and European centers USA: 17 Ch/Ad Ca; 68 A Ca; 112 A Co Australia: 8 Ch/Ad Ca; 32 A Ca Canada: 3 Ch/Ad Ca; 12 A Ca Sweden: 31 Ch/Ad Ca; 58 A Ca; 58 A Co Italy: 90 Ch/Ad Ca; 360 A Ca; 360 A Co Greece: 6 Ch/Ad Ca; 72 A Ca; 72 A Co Turkey: 5 Ch/Ad Ca Serbia: 7 Ch/Ad Ca The Netherlands: 66 A Ca; 66 A Co Spain: 34 Ch/Ad Ca; 264 A Ca; 264 A Co France: 32 Ch/Ad Ca For case-case analysis: 932 A cases (≥35 years) matched by study (N=118 Ch/Ad cases) or by the closest geographical area (N=115 Ch/Ad cases) For case-control analysis: 932 A unaffected controls (≥35 years) matched by study (N=88 Ch/Ad cases) or by the closest geographical area (N=145 Ch/Ad cases)