Efficacy of CD34+ Stem Cell Dose in Patients Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation after Total Body Irradiation  Anurag K. Singh, Bipin N. Savani, Paul S. Albert, A. John Barrett  Biology of Blood and Marrow Transplantation  Volume 13, Issue 3, Pages 339-344 (March 2007) DOI: 10.1016/j.bbmt.2006.10.029 Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 (A) A plot of the log HR (relative to the lowest value of CD34+ for no lung dose–reduced TBI) as a function of log-transformed CD34+ dose for all patients. On the original scale (exponentiated log values), the dashed lines correspond to CD34+ dose values of 5.1 and 12.9 × 106 cells/kg. Median survival over this range was at least double the survival associated with the lowest CD 34+ dose. The X value corresponds to the median CD34+ dose on the log scale. Dotted lines are pointwise 95% confidence intervals. (B) This plot shows the relationship between CD34+ dose and mortality with adjustments for lung dose–reduced TBI, CVDC deficit, and age at transplantation. Biology of Blood and Marrow Transplantation 2007 13, 339-344DOI: (10.1016/j.bbmt.2006.10.029) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 A plot of the log HR (relative to the lowest value of CD34+ for no lung dose–reduced TBI) as a function of log-transformed CD34+ dose for patients with and without lung dose–reduced TBI. On the original scale, the dashed lines correspond to values of 5.8 and 13.6 × 106 cells/kg without lung dose reduction and 4.3 and 10.2 × 106 cells/kg with lung dose reduction. These regions of lower mortality correspond to a doubling of median survival relative to the lowest CD34+ value within the no lung dose–reduction group and a 5-fold increase in median survival relative to the lowest CD34+ value in the lung dose–reduction group. The dotted lines are pointwise 95% confidence intervals. Biology of Blood and Marrow Transplantation 2007 13, 339-344DOI: (10.1016/j.bbmt.2006.10.029) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 This is the same as Figure 1A. The first 2 vertical dashed lines (from right to left) show doses corresponding to 4 and 8 × 106 cells/kg as found by Mohty et al. [12] The second and third vertical dashed lines show the boundaries of 8 and 10 × 106 cells/kg as found by Kamel et al. [10] Biology of Blood and Marrow Transplantation 2007 13, 339-344DOI: (10.1016/j.bbmt.2006.10.029) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions