Ch.8 Theta rhythm and bidirectional plasticity in the hippocampus

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Presentation transcript:

Ch.8 Theta rhythm and bidirectional plasticity in the hippocampus Population Coding Ch.8 Theta rhythm and bidirectional plasticity in the hippocampus Summarized by Ko Youngkil 2009/1/6

Content Summary Theta rhythm Theta rhythm’s effect Conclusion Hippocampus activity Long-term potentiation Ca2+ Level Conclusion

Summary The phase of theta rhythm determines the direction of plastic changes for the entire population The rate of learning is faster highest theta power LTP when peak tetanus LTD when trough tetanus Theta rhythm determine the level of Ca2+ Peak tetanus Trough tetanus

Theta rhythm Rhythmic local field potential Theta appeared Absence Walked, ran, sniffed, oriented, reared, REM Absence Eating, drinking, grooming, slow wave sleep Experiments with rodents

Hippocampus activity Without theta rhythm Impairment in a spatial memory task Spatial alternation Delayed non-match to position And so on. Rabbits when the hippocampal EEG has the highest amount of theta power Theta enables associations to form between place cells with adjoining fields

Long-term potentiation (1/2) Long-lasting enhancement of synaptic excitability Long-term depression Long-lasting decrease in the size of evoked potentials Lead to lasting morphological changes at the synapse that alter synapsis

Long-term potentiation (2/2) LTP induced when a tetanus in positive phase of theta LDP Tetanus in negative phase of theta Theta provide selectively decrease or increase synaptic efficacy Peak tetanus Trough tetanus

Ca2+ Level Spike timing dependent plasticity (STDP) Induce LTP By influx of Ca2+ Levels of Ca2+ determine the directionality of plastic changes, so the phase of theta rhythm controls the directionality

Conclusion Hippocampus activity is tightly controlled by theta. Synaptic modification is dependent on theta Intracellular potentials and ion levels are regulated by theta. Macroscopic, microscopic scales