Hereditary Apolipoprotein AI-Associated Amyloidosis in Surgical Pathology Specimens Magdalena Eriksson, Stefan Schönland, Saniye Yumlu, Ute Hegenbart,

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Hereditary Apolipoprotein AI-Associated Amyloidosis in Surgical Pathology Specimens Magdalena Eriksson, Stefan Schönland, Saniye Yumlu, Ute Hegenbart, Hanna von Hutten, Zarina Gioeva, Peter Lohse, Janine Büttner, Hartmut Schmidt, Christoph Röcken The Journal of Molecular Diagnostics Volume 11, Issue 3, Pages 257-262 (May 2009) DOI: 10.2353/jmoldx.2009.080161 Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 1 Biopsies from the six patients with AApoAI amyloidosis.Histological examination of the biopsy and resection specimens revealed homogeneous eosinophilic deposits in H&E-stained sections (left panel). Same areas produced a typical apple green birefringence in polarized light after Congo red (CR) staining (center). Staining with an anti-apoAI antibody (right panel) showed a strong and even immunoreactivity of these amyloid deposits in every patient specimen. Sections from the patients 1–4 and 6 were stained with the alkaline phosphatase system (red color), whereas the section from patient No. 5 was stained with a DAB substrate kit (brown color). Scale bar=100 μm. The Journal of Molecular Diagnostics 2009 11, 257-262DOI: (10.2353/jmoldx.2009.080161) Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 2 Distribution of ApoAI mutations with regard to the proteins secondary structure. The hot spot regions spanning residues 50 to 93 and 170 to 178 are marked in yellow and the twisted blue areas represent the α-helices. The picture of the secondary structure of ApoAI was obtained from the database Jpred at the European Bioinformatics Institute and modified. The Journal of Molecular Diagnostics 2009 11, 257-262DOI: (10.2353/jmoldx.2009.080161) Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions