Bindiya Patel et al. BTS 2018;j.jacbts

Slides:

Advertisements

Similar presentations

Glioma-derived soluble factor(s) enhance IL-10 signaling.

Advertisements

Fig. 2. Comparison of the Th1/Th2 ratio and the percentages of Th1 and Th2 cells between normal and allergic individuals. (A) The Th1/Th2 ratio observed.

Activation of NK cells during the early stage of allergic and fibrotic lung inflammation. Activation of NK cells during the early stage of allergic and.

Interleukin-5–producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy by Frédéric Van Gool, Ari B. Molofsky, Malika.

Resveratrol modulates DSS-induced neutrophils during colitis.

Skin-draining lymph nodes contain dermis-derived CD103− dendritic cells that constitutively produce retinoic acid and induce Foxp3+ regulatory T cells.

Bindiya Patel et al. BTS 2018;3:

Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer by Ou Cao, Eric Dobrzynski,

Volume 35, Issue 4, Pages (October 2011)

by Daniel L. Barber, Katrin D. Mayer-Barber, Lis R. V

Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients by Devi.

Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy by Fumihiko Tsushima, Sheng Yao, Tahiro Shin, Andrew Flies, Sarah.

Volume 21, Issue 13, Pages (December 2017)

IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis

Treg and Teff cell subsets show increased TCR overlap during colitis.

Volume 42, Issue 5, Pages (May 2015)

Volume 21, Issue 5, Pages (October 2017)

B-cell differentiation associates with down-regulation of vimentin expression. B-cell differentiation associates with down-regulation of vimentin expression.

Helicobacter species induce pTreg cell differentiation during homeostasis. Helicobacter species induce pTreg cell differentiation during homeostasis. (A)

Fig. 6. Increased efficacy of immunotherapy in lymphangiogenic B16 melanomas depends on CCR7 signaling before therapy and local activation and expansion.

Immunologic responses after the MN-mediated cancer immunotherapy.

Colonic Treg TCRs (CT2 and CT6) drive Teff cell development in inflammation. Colonic Treg TCRs (CT2 and CT6) drive Teff cell development in inflammation.

PD‐L1 silencing in antigen presenting DCs results in hyperactivated pro‐inflammatory TCRhigh CD8+ T cells. PD‐L1 silencing in antigen presenting DCs results.

Katherine G. MacDonald, BSc, Nicholas A. J

Volume 29, Issue 1, Pages (July 2008)

Bindiya Patel et al. BTS 2018;j.jacbts

Volume 34, Issue 4, Pages (April 2011)

A Two-Step Process for Thymic Regulatory T Cell Development

Regulatory CD4+ T cell–derived IL-10 is important for B cell differentiation and the GC response. Regulatory CD4+ T cell–derived IL-10 is important for.

Mohamed A. Saleh et al. BTS 2016;1:

TNFα-producing CD3+CD4+CD44+ infiltrating cells.

Postoperative changes in blood monocyte subsets.

Bindiya Patel et al. BTS 2018;j.jacbts

Volume 29, Issue 1, Pages (July 2008)

Fig. 5 Treatment with an OX40 agonist antibody of 3-week-old HBVtgRag−/− mice or mice with chronic HBV disease results in an altered immune response to.

PD-1–PD-L1 axis is highly expressed and is not IFNγ-dependent in a subcutaneous murine model of PDA. A, experimental design for establishment of subcutaneous.

Figure 2 CD4+ T-cell subsets fluorescence-activated cell sorting analysis in peripheral blood mononuclear cells of patients with multiple sclerosis treated.

Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells. Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells.

IL-10R-deficient macrophages secrete IL-23, inducing IL-22 secretion by ILC3 and TH17 cells. IL-10R-deficient macrophages secrete IL-23, inducing IL-22.

Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload.

PD-L1 selectively marks circulating NCMs.

Helicobacter species induce pTreg cell differentiation during homeostasis. Helicobacter species induce pTreg cell differentiation during homeostasis. (A)

Protective Regulatory T Cell Generation in Autoimmune Diabetes by DNA Covaccination with Islet Antigens and a Selective CTLA-4 Ligand Yelena Glinka,

Comparison of conventional NSG and hIL-7 expressing NSG humanized mice

Treatment of ob/ob mice with TTR-ASOs reduces adipose tissue inflammation. Treatment of ob/ob mice with TTR-ASOs reduces adipose tissue inflammation. A:

Supplementation of c-Rel–competent Treg cells reverts exacerbated diabetes in c-Rel−/− NOD mice. Supplementation of c-Rel–competent Treg cells reverts.

Transgenic c-Maf mediates upregulation of type 2 cytokines in NOD CD4, but not CD8, cells. Transgenic c-Maf mediates upregulation of type 2 cytokines in.

Overexpression of IL-27 upregulates expression of multiple IR by T cells in vivo. Overexpression of IL-27 upregulates expression of multiple IR by T cells.

CD8 T cells play a critical role in responses of TILs due to BRAF inhibition. CD8 T cells play a critical role in responses of TILs due to BRAF inhibition.

Human Tfr cells do not express CD25.

Inhibition of TGF-β signaling abrogates the conversion of glutamine-deprived CD4+ T cells to Treg cells but cannot support TH1 cell generation. Inhibition.

Treadmill Exercise Capacity at 18 Weeks Post TAC Exercise capacity was evaluated in all study groups at 18 weeks following TAC surgery. (A) Duration (min)

Nanoimmunotherapy production scale-up and evaluation in Apoe−/− mice

Deletion of Tgfbr2 in myeloid cells elevated IFN-γ production in CD8+ T cells, and systemic IFN-γ neutralization diminished metastasis inhibition in Tgfbr2MyeKO.

In vivo bioluminescence imaging of primary tumors and tumor metastasis

PLX51107 demonstrates in vivo antitumor effects in a preclinical model of aggressive leukemia/lymphoma. PLX51107 demonstrates in vivo antitumor effects.

Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex treatment. Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex.

Mice with a B cell–specific loss of Ets1 have reduced marginal zone B cells and increased ASCs. (A) Flow cytometry analysis of CD21 versus CD23 in gated.

Mice with a B cell–specific deletion of Ets1 have increased memory phenotype B cells but no increase in switching to IgG1. Mice with a B cell–specific.

Anti-CD40 activates TAMs and recruits inflammatory monocytes.

Renal Norepinephrine Content, Circulating Renin, Ang II, and Aldosterone Levels at 18 Weeks Post TAC (A) Renal tissue norepinephrine content (ng/ml). (B)

Intratumoral injections of small doses of agonist anti-CD137 mAb to directly act on CD137+ TILs render systemic immunotherapeutic effects that are synergistic.

IL35 regulation of tumor growth is accompanied by suppression of CD4+ effector T-cell activity and expansion of Tregs. IL35 regulation of tumor growth.

Enhanced antitumor effects with combination IL21 and anti–PD-1/anti–Tim-3 therapy. Enhanced antitumor effects with combination IL21 and anti–PD-1/anti–Tim-3.

Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.

IL2Cx alone or in combination with anti–CTLA-4 increases the CD8/Treg ratio in the tumor. IL2Cx alone or in combination with anti–CTLA-4 increases the.

Recruitment of CD8+, CD4+, and Foxp3+ cells into oral lesions in response to anti–PD-1 treatment. Recruitment of CD8+, CD4+, and Foxp3+ cells into oral.

MDSC population in patient peripheral blood.

Varying the MHC-I affinity, TCR affinity or antigen dose alters the phenotype of CD8 T cells ex vivo. Varying the MHC-I affinity, TCR affinity or antigen.

Effect on the recall response of Nrp1 deletion before infection.

Presentation transcript:

Bindiya Patel et al. BTS 2018;j.jacbts.2017.12.006 Ly6ChiCCR2+ Monocyte Depletion Suppresses Cardiac and Lymphoid T-Cell Expansion During Chronic Pressure-Overload HF (A) Flow cytometry gating strategy for identification of cardiac T cells and CD4+ Th1 (IFN-γ+), Th2 (IL-4+), and T-regulatory (Foxp3+) subsets. (B) Representative gate plots of cardiac CD4+ T cells and corresponding tissue quantitation in mice treated with MC21 or IgG 4 weeks after TAC or sham operation. Statistical comparisons for CD4+ T cells performed after logarithmic data transformation as described in text. Quantitation of cardiac CD4+ T-cell subsets (C) and CD3+CD4−CD8+ cardiac T cells (D) in the same groups. (E) Top, representative gate plots of CD4+ and CD8+ T cells in mediastinal lymph nodes (MLN) from IgG- and MC21-treated TAC mice. Bottom, quantitation of CD3+, CD3+CD4+CD8−, and CD3+CD4−CD8+ T cells in the MLN of mice treated with MC21 or IgG 4 weeks after TAC or sham operation. *p < 0.05; n = 6 to 8 per group. Bindiya Patel et al. BTS 2018;j.jacbts.2017.12.006 ©2018 by American College of Cardiology