Assessment of intracerebral micro‐hemorrhages in APP23‐transgenic mice, dosed orally with CNP520 at 30 mg/kg for 3 months Assessment of intracerebral micro‐hemorrhages.

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Assessment of intracerebral micro‐hemorrhages in APP23‐transgenic mice, dosed orally with CNP520 at 30 mg/kg for 3 months Assessment of intracerebral micro‐hemorrhages in APP23‐transgenic mice, dosed orally with CNP520 at 30 mg/kg for 3 months AAssessment of brain lesion volume by longitudinal magnetic resonance imaging. For description of the method, see Beckmann et al (2016). White bars show the APP23‐typical age‐dependent increase in lesion volume, and black bars show the effect of CNP520. The antibody β1 serves as positive control and shows enhancement of lesion volume over time. ANOVA test with random effects was applied. Shown is average ± SEM; for n numbers, see table in panel (B). Non‐underlined P‐values: comparison to baseline, only significant differences are shown. Underlined P‐values: significant differences between treatment groups at the given time point.BResults of histopathological staining using Perl's staining and H&E staining. APP23 (21 months of age) was sacrificed; four brain sections were processed and stained with hematoxylin and eosin (H&E) and Prussian blue for hemosiderin deposits. Levels 2, 3, and 4, and one additional slide at hypothalamus level (level 2’). Brain sections stained with hematoxylin and eosin and with Perl's Prussian blue were examined under a light microscope. The distribution, size, and staining intensity of hemosiderin deposits in Perl's Prussian blue‐stained sections were assessed and recorded. Table lists the number of animals affected, and the percentage. Ulf Neumann et al. EMBO Mol Med. 2018;emmm.201809316 © as stated in the article, figure or figure legend