V. B. Kraus, B. Burnett, J. Coindreau, S. Cottrell, D. Eyre, M

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Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis  V.B. Kraus, B. Burnett, J. Coindreau, S. Cottrell, D. Eyre, M. Gendreau, J. Gardiner, P. Garnero, J. Hardin, Y. Henrotin, D. Heinegård, A. Ko, L.S. Lohmander, G. Matthews, J. Menetski, R. Moskowitz, S. Persiani, A.R. Poole, J.-C. Rousseau, M. Todman  Osteoarthritis and Cartilage  Volume 19, Issue 5, Pages 515-542 (May 2011) DOI: 10.1016/j.joca.2010.08.019 Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Continuum of OA stages as paradigms for structure modifying OA trials. Osteoarthritis and Cartilage 2011 19, 515-542DOI: (10.1016/j.joca.2010.08.019) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Conceptual framework for biomarker qualification. Osteoarthritis and Cartilage 2011 19, 515-542DOI: (10.1016/j.joca.2010.08.019) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

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