Heavy Smoking Before Coronary Surgical Procedures Affects the Native Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 Gene Expression in Saphenous.

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Heavy Smoking Before Coronary Surgical Procedures Affects the Native Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 Gene Expression in Saphenous Vein Conduits Sun Yongxin, MD, Ding Wenjun, MD, Wei Qiang, MD, Shi Yunqing, MD, Zhu Liming, MD, Wang Chunsheng, MD The Annals of Thoracic Surgery Volume 95, Issue 1, Pages 55-61 (January 2013) DOI: 10.1016/j.athoracsur.2012.08.073 Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Immunostaining of matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) in saphenous vein (SV) conduits (diaminobenzidine stain, original magnification ×100). The representative immunohistochemical analysis shows MMP-2, MMP-9, TIMP-1, and TIMP-2 immunostaining in SV conduits of patients with different smoking status. The Annals of Thoracic Surgery 2013 95, 55-61DOI: (10.1016/j.athoracsur.2012.08.073) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Tissue MMP-2, MMP-9, TIMP-1, and TIMP-2 protein levels in saphenous vein (SV) conduits. A representative image of Western blotting shows the tissue MMP-2, MMP-9, TIMP-1, and TIMP-2 protein levels in SVs of different groups. (MMP = matrix metalloproteinase; MW = molecular weight; TIMP = tissue inhibitors of metalloproteinases.) The Annals of Thoracic Surgery 2013 95, 55-61DOI: (10.1016/j.athoracsur.2012.08.073) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions