Volume 64, Issue 5, Pages (November 2003)

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Volume 64, Issue 5, Pages 1671-1674 (November 2003) VHL down-regulation and differential localization as mechanisms in tumorigenesis Yih-Horng Shiao, Asta Forsti, Lars Egevad, Lucy M. Anderson, Per Lindblad, Kari Hemminki Kidney International Volume 64, Issue 5, Pages 1671-1674 (November 2003) DOI: 10.1046/j.1523-1755.2003.00257.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Determination of von Hippel-Lindau (VHL) antibody specificity using normal kidneys and cancer-positive controls (magnification, 200×). Nonneoplastic areas of kidney: Ig32 antibody (A and C); Ab-1 antibody (B); IgG1 isotype antibody (D). Breast cancer: Ig32 antibody (E); omission of Ig32 antibody (F). Kidney International 2003 64, 1671-1674DOI: (10.1046/j.1523-1755.2003.00257.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 von Hippel-Lindau (VHL) brown immunosignal from Ig32 antibody in renal cell carcinomas. Cell membrane (A and B) (magnification, 200×); cytoplasm (C and D) (magnification, 200×); comparison of signal between nonneoplastic [on the right (E) and at the top-right corner (F)] (magnification, 100×) and corresponding tumor areas [on the left (E) and at the bottom (F)]. Kidney International 2003 64, 1671-1674DOI: (10.1046/j.1523-1755.2003.00257.x) Copyright © 2003 International Society of Nephrology Terms and Conditions