E. Warwick Daw, Simon C. Heath, Ellen M. Wijsman

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Multipoint Oligogenic Analysis of Age-at-Onset Data with Applications to Alzheimer Disease Pedigrees E. Warwick Daw, Simon C. Heath, Ellen M. Wijsman The American Journal of Human Genetics Volume 64, Issue 3, Pages 839-851 (March 1999) DOI: 10.1086/302276 Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 1 Hypothetical example with two genotype onset distributions, A and B. An unaffected 75-year-old will be assigned an age at onset from the hatched area under the B curve, if that person is currently assigned genotype B, and from the hatched area under the A curve, if currently assigned genotype A. Heights a and b indicate the relative likelihoods of genotypes A and B, respectively, for an individual with onset at age 75 years. The American Journal of Human Genetics 1999 64, 839-851DOI: (10.1086/302276) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 2 Histogram of chromosome location vs. variance, for every QTL placed on chromosome 14 in all iterations of one analysis run, using all available families and 12 markers on chromosome 14. Arrows indicate marker locations; line indicates PS1 location. Contour lines below histogram are at 25, 50, 100, 200, 400, 800, 1,600, and 3,200 counts. The American Journal of Human Genetics 1999 64, 839-851DOI: (10.1086/302276) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 3 Location of each QTL placed on chromosome 14, in each iteration of the all-families analysis. Arrows indicate marker location; line indicates PS1 location. The American Journal of Human Genetics 1999 64, 839-851DOI: (10.1086/302276) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 4 Variance of each QTL not placed on chromosome 14, in each iteration in the all-families analysis. The American Journal of Human Genetics 1999 64, 839-851DOI: (10.1086/302276) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 5 Histogram of chromosome location vs. variance, for every QTL placed on chromosome 1, in all iterations of one analysis run, using the VG families and 40 markers on chromosomes 1, 5, and 14. Arrows indicate the location of the 19 markers on chromosome 1. The American Journal of Human Genetics 1999 64, 839-851DOI: (10.1086/302276) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 6 Histogram of location vs. variance, for every QTL placed on chromosome 5, in the VG-families analysis run. Arrows indicate the 11 marker locations. The American Journal of Human Genetics 1999 64, 839-851DOI: (10.1086/302276) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 7 Histogram of locations vs. variance, for every QTL placed on chromosome 14, in the VG-families analysis run. Arrows indicate the 10 marker locations. The American Journal of Human Genetics 1999 64, 839-851DOI: (10.1086/302276) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 8 Variance of each QTL not placed on chromosomes 1, 5, or 14, in each iteration of the VG-families analysis. The American Journal of Human Genetics 1999 64, 839-851DOI: (10.1086/302276) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 9 Location of each QTL placed on chromosome 1, in each iteration of the VG families analysis. Arrows indicate marker locations; line indicates PS2 location. The American Journal of Human Genetics 1999 64, 839-851DOI: (10.1086/302276) Copyright © 1999 The American Society of Human Genetics Terms and Conditions