Long-term outcomes of nonconditioned patients with severe combined immunodeficiency transplanted with HLA-identical or haploidentical bone marrow depleted.

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Presentation transcript:

Long-term outcomes of nonconditioned patients with severe combined immunodeficiency transplanted with HLA-identical or haploidentical bone marrow depleted of T cells with anti-CD6 mAb Niraj C. Patel, MD, MS, Javier Chinen, MD, PhD, Howard M. Rosenblatt, MD, Imelda C. Hanson, MD, Betty S. Brown, MS, Mary E. Paul, MD, Stuart L. Abramson, MD, PhD, Jerome Ritz, MD, William T. Shearer, MD, PhD Journal of Allergy and Clinical Immunology Volume 122, Issue 6, Pages 1185-1193 (December 2008) DOI: 10.1016/j.jaci.2008.10.030 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Kaplan-Meier curve demonstrating survival of patients with SCID, including 20 patients whose donor bone marrow was treated with anti-CD6 mAb (solid line) and 5 patients who received unmanipulated bone marrow (dotted line). Journal of Allergy and Clinical Immunology 2008 122, 1185-1193DOI: (10.1016/j.jaci.2008.10.030) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Lymphocytes in patients with SCID: CD3+ T cells (A), NK+ cells (B), and CD19+ B cells (C) in 10 survivors who received anti-CD6 T cell–depleted bone marrow; and CD3+ T cells (D), NK+ cells (E), and CD19+ B cells (F) in 5 survivors who received unmanipulated bone marrow. The 10th and 90th percentile normal values are represented by shaded areas.31 Journal of Allergy and Clinical Immunology 2008 122, 1185-1193DOI: (10.1016/j.jaci.2008.10.030) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Lymphocytes in patients with SCID: CD3+ T cells (A), NK+ cells (B), and CD19+ B cells (C) in 10 survivors who received anti-CD6 T cell–depleted bone marrow; and CD3+ T cells (D), NK+ cells (E), and CD19+ B cells (F) in 5 survivors who received unmanipulated bone marrow. The 10th and 90th percentile normal values are represented by shaded areas.31 Journal of Allergy and Clinical Immunology 2008 122, 1185-1193DOI: (10.1016/j.jaci.2008.10.030) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions