Necrotizing enterocolitis is one disease with many origins and potential means of prevention  Phillip V. Gordon, Jonathan R. Swanson  Pathophysiology  Volume 21, Issue 1, Pages 13-19 (February 2014) DOI: 10.1016/j.pathophys.2013.11.015 Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Summation/consolidation of data about NEC, including time of presentation, percent mortality and incidence of disease stratified by gestational age. Left-sided y-axis equals day of onset indicated by the sphere centers. The sphere diameters indicate the percent of total NEC that presented on that day of life (mean for the gestational age group), and correlate with the x-axis below. The gray columns indicate the percent mortality (right side y-axis). Data for the extrapolations in this figure are based upon summarized data from Refs. [30–33]. In cases where precise data was unavailable in the units needed (for example, if the data were available by birth weight instead of gestational age), the data were extrapolated using the assumption that the population as a whole was appropriate for gestational age and the datasets were representative of a common disease entity. For example, two single center reports were used to overlay the timing of NEC onset onto the national dataset of incidence and mortality. Pathophysiology 2014 21, 13-19DOI: (10.1016/j.pathophys.2013.11.015) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Schematic of early versus late risk factors for necrotizing enterocolitis. Pathophysiology 2014 21, 13-19DOI: (10.1016/j.pathophys.2013.11.015) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Schematic depicting predicted subgroup overlap between necrotizing enterocolitis subsets. Pathophysiology 2014 21, 13-19DOI: (10.1016/j.pathophys.2013.11.015) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions