H. J. Kim, H. -C. Lee, Y. S. Jung, J. Lee, J. J. Min, D. -M. Hong, E

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Effect of palonosetron on the QTc interval in patients undergoing sevoflurane anaesthesia H.J. Kim, H.-C. Lee, Y.S. Jung, J. Lee, J.J. Min, D.-M. Hong, E.-K. Choi, S. Oh, Y. Jeon British Journal of Anaesthesia Volume 112, Issue 3, Pages 460-468 (March 2014) DOI: 10.1093/bja/aet335 Copyright © 2014 The Author(s) Terms and Conditions

Fig 1 Flow diagram. British Journal of Anaesthesia 2014 112, 460-468DOI: (10.1093/bja/aet335) Copyright © 2014 The Author(s) Terms and Conditions

Fig 2 Changes in HR (a) and MAP (b) during the perioperative period. Baseline; 2, 10, 15, 30, 60, and 90 min after administration of palonosetron or placebo in the operating theatre; R, in the recovery room; R3 and R10, 3 and 10 min after administration of palonosetron or placebo in the recovery room. *P<0.05 vs the baseline value. Error bars indicate sd. British Journal of Anaesthesia 2014 112, 460-468DOI: (10.1093/bja/aet335) Copyright © 2014 The Author(s) Terms and Conditions

Fig 3 Changes in QTc intervals during the perioperative period. QTc intervals were calculated using Bazett's (QTcB), Fridericia's (QTcF), and Hodges formulas (QTcH). Baseline; 2, 10, 15, 30, 60, and 90 min after administration of palonosetron or placebo in the operating theatre; R, in the recovery room; R3 and R10, 3 and 10 min after administration of palonosetron or placebo in the recovery room. *P<0.05 compared with the baseline value. Error bars indicate sd. British Journal of Anaesthesia 2014 112, 460-468DOI: (10.1093/bja/aet335) Copyright © 2014 The Author(s) Terms and Conditions