High inspired oxygen concentration increases the speed of onset of remifentanil- induced respiratory depression A Dahan, M Douma, E Olofsen, M Niesters

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High inspired oxygen concentration increases the speed of onset of remifentanil- induced respiratory depression A Dahan, M Douma, E Olofsen, M Niesters British Journal of Anaesthesia Volume 116, Issue 6, Pages 878-879 (June 2016) DOI: 10.1093/bja/aew130 Copyright © 2016 The Author(s) Terms and Conditions

Fig 1 Examples of data fits of the effect of remifentanil on breathing obtained in three volunteers. Each blue open circle is one breath; the green line is the predicted ventilation; and the pink filled trangle is the remifentanil bolus administration (50 µg). (a and b) Data sets obtained during air breathing. (c) Data set obtained during breathing of high inspired oxygen. British Journal of Anaesthesia 2016 116, 878-879DOI: (10.1093/bja/aew130) Copyright © 2016 The Author(s) Terms and Conditions

Fig 2 Simulation of the effect of administration of multiple remifentanil boluses (30 µg) on ventilation during conditions of no pain (green) and during conditions of constant mild to moderate pain (blue), causing an increase in baseline ventilation of ∼50%. British Journal of Anaesthesia 2016 116, 878-879DOI: (10.1093/bja/aew130) Copyright © 2016 The Author(s) Terms and Conditions