Immunologic function and survival in hemodialysis patients

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Presentation transcript:

Immunologic function and survival in hemodialysis patients Paul L. Kimmel, Terry M. Phillips, Samuel J. Simmens, Rolf A. Peterson, Karen L. Weihs, Sylvan Alleyne, Illuminado Cruz, Jack A. Yanovski, Judith H. Veis Kidney International Volume 54, Issue 1, Pages 236-244 (July 1998) DOI: 10.1046/j.1523-1755.1998.00981.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Distribution of immune parameters in 230 stable outpatients with end-stage renal disease (ESRD) treated with hemodialysis. Distributions of IL-2 (A), CH50 (B), T-cell number (C) and T-cell function (D) show moderate skew (skewness values ranging from -0.45 to 0.33). These factors were associated with improved patient survival. Kidney International 1998 54, 236-244DOI: (10.1046/j.1523-1755.1998.00981.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Distribution of immune parameters in 230 stable outpatients with ESRD treated with hemodialysis. Highly positively skewed distributions of circulating IL-1 (A), IL-6 (B), TNF-α (C) and IL-13 (D) levels were noted in this population (skewness values ranging from 1.25 to 3.3). Most patients’ values were within a lower range, with a minority having extremely elevated values. These factors were associated with increased patient mortality. Kidney International 1998 54, 236-244DOI: (10.1046/j.1523-1755.1998.00981.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 236-244DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 236-244DOI: (10.1046/j.1523-1755.1998.00981.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 236-244DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 236-244DOI: (10.1046/j.1523-1755.1998.00981.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 236-244DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 236-244DOI: (10.1046/j.1523-1755.1998.00981.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 236-244DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 236-244DOI: (10.1046/j.1523-1755.1998.00981.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 236-244DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 236-244DOI: (10.1046/j.1523-1755.1998.00981.x) Copyright © 1998 International Society of Nephrology Terms and Conditions