Volume 129, Issue 3, Pages (September 2005)

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Volume 129, Issue 3, Pages 874-884 (September 2005) Gene-Expression Profiling Predicts Recurrence in Dukes’ C Colorectal Cancer Diego Arango, Paivi Laiho, Antti Kokko, Pia Alhopuro, Heli Sammalkorpi, Reijo Salovaara, Daniel Nicorici, Sampsa Hautaniemi, Hafid Alazzouzi, Jukka–Pekka Mecklin, Heikki Järvinen, Akseli Hemminki, Jaakko Astola, Simo Schwartz, Lauri A. Aaltonen Gastroenterology Volume 129, Issue 3, Pages 874-884 (September 2005) DOI: 10.1053/j.gastro.2005.06.066 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Hierarchical clustering. (A) Results of an unsupervised hierarchical clustering of all 25 Dukes’ C colorectal tumors with the 5102 genes expressed at detectable levels in all samples. Each column represents a sample, and each row, a gene. Gene expression above and below the median is depicted in red and green, respectively. The blue and yellow squares in the top bar indicate tumors from patients with bad prognosis and good prognosis, respectively. (B) Disease-free survival of patients in the sub-branch dominated by bad prognosis patients (right) and the other 2 main sub-branches (Kaplan–Meier plot). The log-rank P value is shown. Gastroenterology 2005 129, 874-884DOI: (10.1053/j.gastro.2005.06.066) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 2 Supervised K-nearest neighbors (KNN) classifier. (A) Accuracy of a KNN classifier with 5 neighbors as a function of the number of genes used by the classifier. (B) Disease-free survival of patients predicted to have good and bad long-term prognosis by a classifier based on the 5 nearest neighbors and 17 genes (Kaplan–Meier plot). The log-rank P value is shown. Gastroenterology 2005 129, 874-884DOI: (10.1053/j.gastro.2005.06.066) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 3 Genetic markers of prognosis. Disease-free survival of Dukes’ C colorectal cancer patients by (A) TP53 and (B) K-RAS mutational status and (C) allelic imbalance in chromosome 18q (Kaplan–Meier plots). Log-rank P values are shown. Gastroenterology 2005 129, 874-884DOI: (10.1053/j.gastro.2005.06.066) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 4 RHOA immunohistochemical staining. (A) Representative examples of normal colon samples (1) and tumors showing low (2), intermediate (3 and 4), or high (5) RHOA immunostaining (original magnification, 200×). Higher-power magnification is shown in the lower part. (B) Overall and disease-free survival of 137 Dukes’ C colorectal cancer patients with high and low RHOA tumor levels (Kaplan–Meier plots). Log-rank P values are shown. Gastroenterology 2005 129, 874-884DOI: (10.1053/j.gastro.2005.06.066) Copyright © 2005 American Gastroenterological Association Terms and Conditions