Immune Quiescence and Hepatitis B Virus: Tolerance Has Its Limits Victoria M. Velazquez, Arash Grakoui  Gastroenterology  Volume 143, Issue 3, Pages 529-532 (September 2012) DOI: 10.1053/j.gastro.2012.07.089 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 The natural progression of CHB through phases of (i) tolerance, (ii) activation, and (iii) control. Although T-cell priming during the tolerant phase of CHB is not thought to occur, Kennedy et al3 demonstrate a clear distinction between the presence of HBV-specific T cells (dashed red) and actual control of viral replication (solid red). This distinction is most exaggerated in younger patients. Potential mechanisms that might contribute to a ‘quiescent’ state of the newly discovered T-cell responses in vivo are highlighted. Gastroenterology 2012 143, 529-532DOI: (10.1053/j.gastro.2012.07.089) Copyright © 2012 AGA Institute Terms and Conditions