Pyruvate as a Pivot Point for Oncogene-Induced Senescence

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Pyruvate as a Pivot Point for Oncogene-Induced Senescence Benjamin A. Olenchock, Matthew G. Vander Heiden Cell Volume 153, Issue 7, Pages 1429-1430 (June 2013) DOI: 10.1016/j.cell.2013.06.001 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Pyruvate Is a Critical Hub in the Metabolic Network, Interfacing with Multiple Anabolic and Catabolic Pathways A schematic is provided for how pyruvate links to metabolic pathways including the mitochondrial TCA cycle, glycolysis, fatty acid synthesis, nucleotide synthesis, and alanine production. Where malic enzyme lies in relation to pyruvate metabolism is also shown. Kaplon et al. suggest that oncogenic BRAFV600E brings about OIS by inducing PDP2 and suppressing PDK1, which together lessen phosphorylation of the pyruvate dehydrogenase complex (PDH), increase PDH flux, and favor catabolic metabolism. This state is not conducive to cell proliferation. Cell 2013 153, 1429-1430DOI: (10.1016/j.cell.2013.06.001) Copyright © 2013 Elsevier Inc. Terms and Conditions