Volume 55, Issue 6, Pages (June 1999)

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Volume 55, Issue 6, Pages 2362-2367 (June 1999) Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability Andrew A. Kramer, Gilbert Postler, Khaled F. Salhab, Cynthia Mendez, Larry C. Carey, Hamid Rabb Kidney International Volume 55, Issue 6, Pages 2362-2367 (June 1999) DOI: 10.1046/j.1523-1755.1999.00460.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Pulmonary vascular permeability (PVP) as quantitated by Evans blue dye spectrophotometric analysis. Symbols are: (▪) sham operation; () ischemia/reperfusion injury (IRI). PVP was assessed at 1, 24, 48, and 96hours after IRI. Rats undergoing renal IRI had a significant increase in PVP at 24 and 48hours after IRI compared with sham-operated rats (P < 0.05, Student's t-test). Kidney International 1999 55, 2362-2367DOI: (10.1046/j.1523-1755.1999.00460.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Pulmonary vascular permeability (PVP) 48hours after renal ischemia/reperfusion injury (IRI) in rats pretreated with the macrophage pacifant CNI-1493 or saline vehicle. Pretreatment with CNI-1493 significantly reduced PVP after renal IRI (P < 0.05, Student's t-test). Kidney International 1999 55, 2362-2367DOI: (10.1046/j.1523-1755.1999.00460.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Serum creatinine and blood urea nitrogen (BUN) at 1, 24, 48, and 96hours after renal ischemia/reperfusion injury (IRI). Symbols are: (▿) renal IRI; (•) sham operated. Increases in serum creatinine and BUN paralleled the development of PVP and were statistically increased over sham-operated animals at 24 and 48hours (P < 0.05, Student's t-test). Kidney International 1999 55, 2362-2367DOI: (10.1046/j.1523-1755.1999.00460.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 4 Pulmonary histology 24hours after renal ischemia/reperfusion injury (IRI). Sham-operated rats had a paucity of interstitial red blood cells or edema at 24hours viewed at low (×20; A) or high (×40; B) power. Renal IRI resulted in marked pulmonary vascular congestion with red blood cells and focal intra-alveolar hemorrhage (C). Renal IRI also led to interstitial edema, but no hyaline membranes (D). Treatment of rats undergoing renal IRI with CNI-1493 led to a marked decrease in hemorrhage (E); however, an accumulation of interstitial red blood cells and increased edema was still prominent (F). Publication of this figure in color was assisted by educational grants from Merck and Co., Inc., and Astra Pharmaceuticals. Kidney International 1999 55, 2362-2367DOI: (10.1046/j.1523-1755.1999.00460.x) Copyright © 1999 International Society of Nephrology Terms and Conditions