Intestinal Microbiota Injury during Allo-Hct is Generalizable across Transplantation Centers and is Associated with Increased Mortality, Broad-Spectrum.

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Presentation transcript:

Intestinal Microbiota Injury during Allo-Hct is Generalizable across Transplantation Centers and is Associated with Increased Mortality, Broad-Spectrum Antibiotics, and Decreased Calorie Intake Jonathan U. Peled, Antonio Gomes, Marissa Lubin Buchan, Christoph Stein-Thoeringer, John Slingerland, Ann E. Slingerland, Daniela Weber, Anthony D. Sung, Molly Maloy, Tatanisha Peets, Boglarka Gyurkocza, Sergio A. Giralt, Robert R. Jenq, Ying Taur, Joao Xavier, Eric G. Pamer, Nelson J. Chao, Ernst Holler, Marcel R.M. van den Brink Biology of Blood and Marrow Transplantation Volume 24, Issue 3, Pages S21-S22 (March 2018) DOI: 10.1016/j.bbmt.2017.12.008 Copyright © 2017 Terms and Conditions

Figure 1 (A and B) Each point is a stool sample color-coded by transplantation center. In (A) the samples are projected in tSNE space according to microbiota composition; green-shaded zone indicates a cluster of samples exhibiting enterococcus domination. In (B), Simpson reciprocal α-diversity index (S) is plotted against time. Larger S values are more diverse; moving averages are indicated by lines. (C) difference (Δ) in S between outpatient stool samples and the last inpatient sample collected prior to dischange for each patient. (D) Survival probabilities of patients from MSKCC and Regensburg according above- or below-median S of a single sample per patient collected closest to HSCT day 14 ± 7. Biology of Blood and Marrow Transplantation 2018 24, S21-S22DOI: (10.1016/j.bbmt.2017.12.008) Copyright © 2017 Terms and Conditions