LV.IDS and LV.IDS.ApoEII improve brain‐specific IDS activity and express supra‐physiological levels of active IDS in peripheral organs LV.IDS and LV.IDS.ApoEII.

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LV.IDS and LV.IDS.ApoEII improve brain‐specific IDS activity and express supra‐physiological levels of active IDS in peripheral organs LV.IDS and LV.IDS.ApoEII improve brain‐specific IDS activity and express supra‐physiological levels of active IDS in peripheral organs A–DVector copy number measured in (A) bone marrow, (B) brain, (C) spleen, and (D) WBCs, n = 6 mice/group.E–IIDS enzyme activity levels measured in organs taken at 8 months of age, including (E) bone marrow, (F) brain, (G) plasma, (H) spleen, and (I) heart from control and treated mice, n = 6 mice/group.JVCN in WBCs vs. enzyme activity in plasma in individual mice.K–MLevels of lysosomal enzyme β‐hexosaminidase activity in (K) the plasma, (L) spleen, and (M) brain of 8‐month‐old mice, n = 6 mice/group.Data information: All data are mean ± SEM. One‐way ANOVA, nsP > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. MPS II; other comparisons are indicated by brackets. For IDS enzyme activity, log‐transformed data were used for statistical analysis. Hélène FE Gleitz et al. EMBO Mol Med. 2018;10:e8730 © as stated in the article, figure or figure legend