Volume 373, Issue 9658, Pages (January 2009)

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Volume 373, Issue 9658, Pages 125-136 (January 2009) Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study The Lancet Volume 373, Issue 9658, Pages 125-136 (January 2009) DOI: 10.1016/S0140-6736(08)61766-3 Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 1 ASTEC trial design The Lancet 2009 373, 125-136DOI: (10.1016/S0140-6736(08)61766-3) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 2 Profile of ASTEC surgical trial We did not collect logs of patients assessed for eligibility. TAH=total abdominal hysterectomy. BSO=bilateral salpingo-oophorectomy. H=hysterectomy. The Lancet 2009 373, 125-136DOI: (10.1016/S0140-6736(08)61766-3) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 3 Overall survival (A), disease and treatment-related deaths (B), and recurrence-free survival (C) by treatment group The Lancet 2009 373, 125-136DOI: (10.1016/S0140-6736(08)61766-3) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 4 Kaplan-Meier plots for the two treatment groups for overall and recurrence-free survival together with the model curves from fitting the Royston-Parmar parametric model A and B show Kaplan-Meier estimates, with Royston-Parmar parametric model fitted. C and D show the absolute difference over time (95% CI) in survival from Royston-Parmar parametric model. The Lancet 2009 373, 125-136DOI: (10.1016/S0140-6736(08)61766-3) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 5 Effect of lymphadenectomy on overall survival (A) and recurrence-free survival (B) in women in different risk groups of recurrence O–E=observed minus expected. Outer bars show 99% CI, inner bars show 95% CI. The Lancet 2009 373, 125-136DOI: (10.1016/S0140-6736(08)61766-3) Copyright © 2009 Elsevier Ltd Terms and Conditions