Inhaled allergen bronchoprovocation tests

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Inhaled allergen bronchoprovocation tests Zuzana Diamant, MD, PhD, Gail M. Gauvreau, PhD, Don W. Cockcroft, MD, FRCPC, FAAAAI, Louis-Philippe Boulet, MD, FRCP(C), Peter J. Sterk, MD, PhD, Frans H.C. de Jongh, PhD, Barbro Dahlén, MD, PhD, Paul M. O’Byrne, MB, FRCP(C) Journal of Allergy and Clinical Immunology Volume 132, Issue 5, Pages 1045-1055.e6 (November 2013) DOI: 10.1016/j.jaci.2013.08.023 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Mechanism of action of various standardized airway challenges applied in clinical practice and clinical research. Modified from O'Byrne et al.3 Journal of Allergy and Clinical Immunology 2013 132, 1045-1055.e6DOI: (10.1016/j.jaci.2013.08.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 EAR and LAR after high-dose inhaled allergen challenge. Journal of Allergy and Clinical Immunology 2013 132, 1045-1055.e6DOI: (10.1016/j.jaci.2013.08.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 The relationship between the maximal decrease in FEV1 from baseline during the EAR (left) and the LAR (right) after 2 consecutive allergen challenges performed in the same subjects (n = 28). Reproduced with permission from Inman et al.35 Journal of Allergy and Clinical Immunology 2013 132, 1045-1055.e6DOI: (10.1016/j.jaci.2013.08.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 A, Relationship between the AUC during the LAR after 2 subsequent allergen challenges performed in the same subjects at least 3 weeks apart (n = 17, left) and power curves allowing estimation of sample size for expected attenuation of the LAR AUC (in a crossover study, right). Reproduced with permission from Gauvreau et al.49 B, Relationship between the percentage of sputum eosinophils at 7 hours (solid circles) and 24 hours (open circles) after 2 consecutive allergen challenges performed in the same subjects at least 3 weeks apart (n = 17, left) and derived power curves allowing estimation of sample size for expected attenuation of the allergen-induced percentage sputum eosinophils (crossover study, right). Reproduced with permission from Gauvreau et al.49 Journal of Allergy and Clinical Immunology 2013 132, 1045-1055.e6DOI: (10.1016/j.jaci.2013.08.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Effect of inhaled allergen challenge on nonspecific airway hyperresponsiveness PC20(histamine). Permission obtained from Cockroft et al.E21 Journal of Allergy and Clinical Immunology 2013 132, 1045-1055.e6DOI: (10.1016/j.jaci.2013.08.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Effect of inhaled allergen challenge on sputum inflammatory markers. Gauvreau et al,E27 reprinted with permission of the American Thoracic Society. Copyright © 2012 American Thoracic Society. Journal of Allergy and Clinical Immunology 2013 132, 1045-1055.e6DOI: (10.1016/j.jaci.2013.08.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions