Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity Sinforiano J. Posadas, PhDa, Antonia Padial,

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Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity Sinforiano J. Posadas, PhDa, Antonia Padial, MDa, Maria J. Torres, PhD, MDb, Cristobalina Mayorga, PhDb, Laura Leyva, PhD, MDb, Elena Sanchez, MDa, Javier Alvarez, PhDa, Antonino Romano, MDc, Carlos Juarez, PhD, MDb, Miguel Blanca, PhD, MDa Journal of Allergy and Clinical Immunology Volume 109, Issue 1, Pages 155-161 (January 2002) DOI: 10.1067/mai.2002.120563 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Comparison by Pearson correlation coefficient between the expression of perforin and the expression of GrB in the 15 cases studied. Journal of Allergy and Clinical Immunology 2002 109, 155-161DOI: (10.1067/mai.2002.120563) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 mRNA determination of TNF-α (A ), perforin (B ), and GrB (C ) in 15 patients (white boxes) and 21 controls (gray boxes) 24 hours and 30 days after the initiation of the reaction. Data were analyzed by Mann-Whitney test. ***P < .001. **P < .006. Journal of Allergy and Clinical Immunology 2002 109, 155-161DOI: (10.1067/mai.2002.120563) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 3 Comparison by Spearman correlation coefficient of disease severity and mRNA expression of TNF-α (A ), perforin (B ), and GrB (C ). Disease severity was classified in 4 categories—A, B, C, and D (of increasing severity in that order), corresponding to 1, 2, 3, and 4 on the y axis. The association was significant in all cases—more so for the 2 cytotoxic markers perforin and GrB. Journal of Allergy and Clinical Immunology 2002 109, 155-161DOI: (10.1067/mai.2002.120563) Copyright © 2002 Mosby, Inc. Terms and Conditions