Diagnostic Performance of Four-dimensional CT and Sestamibi SPECT/CT in Localizing Parathyroid Adenomas in Primary Hyperparathyroidism Combined four-dimensional.

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Diagnostic Performance of Four-dimensional CT and Sestamibi SPECT/CT in Localizing Parathyroid Adenomas in Primary Hyperparathyroidism Combined four-dimensional CT with sestamibi SPECT/CT and four-dimensional CT alone had similar diagnostic performance (area under the receiver operating characteristic curve [AUC], 0.88 and 0.87, respectively; P = .82). Four-dimensional CT had higher diagnostic performance than sestamibi SPECT/CT (AUC, 0.88 vs 0.78, respectively; P < .001). Four-dimensional CT had higher sensitivity than sestamibi SPECT/CT in all patients (79% vs 58%, respectively; P < .001) and in patients with single-gland disease (92% vs 75%, respectively; P < .001) and multigland disease (58% vs 31%, respectively; P < .001). Yeh R et al. Published Online: Mar 5, 2019 https://doi.org/10.1148/radiol.2019182122 In a 69-year-old woman with primary hyperparathyroidism, axial sestamibi SPECT/CT shows focal sestamibi uptake localizing to a single abnormal left lower parathyroid gland (arrow).