Errors at mitotic segregation early in oogenesis and at first meiotic division in oocytes from donor females: Comparative genomic hybridization analyses.

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Presentation transcript:

Errors at mitotic segregation early in oogenesis and at first meiotic division in oocytes from donor females: Comparative genomic hybridization analyses in metaphase II oocytes and their first polar body Albert Obradors, Ph.D., Mariona Rius, M.Sc., Juliana Cuzzi, Ph.D., Gemma Daina, M.Sc., Cristina Gutiérrez-Mateo, Ph.D., Aïda Pujol, Ph.D., Fernando Marina, Ph.D., Carmen Márquez, Ph.D., Jordi Benet, Ph.D., Joaquima Navarro, Ph.D. Fertility and Sterility Volume 93, Issue 2, Pages 675-679 (January 2010) DOI: 10.1016/j.fertnstert.2009.08.050 Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) CGH result of the 27 aneuploid 1PB-MIIs detected. The oocytes code, the donor, the maturation process (F for “fresh” or IVM), the cytogenetic result, and the aneuploidy origin are also included. (B) CGH profiles of oocyte F10 (1PB and MII) showing the two aneuploidy mechanisms described in this work; a first meiotic error affecting chromosome 18 and a gain of chromosome 16 in the MII due to origination from an aneuploid oogonium for that chromosome. Chromosome 17 is euploid in both cells. Fertility and Sterility 2010 93, 675-679DOI: (10.1016/j.fertnstert.2009.08.050) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions