Relationship between time of reperfusion and E-selectin expression, neutrophil recruitment, and germ cell apoptosis after testicular ischemia in a rat.

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Relationship between time of reperfusion and E-selectin expression, neutrophil recruitment, and germ cell apoptosis after testicular ischemia in a rat model  Igor Sukhotnik, M.D., Robert Greenblatt, M.D., Katya Voskoboinik, B.A., Michael Lurie, M.D., Arnold G. Coran, M.D., Jorge G. Mogilner, M.D.  Fertility and Sterility  Volume 90, Issue 4, Pages 1517-1522 (October 2008) DOI: 10.1016/j.fertnstert.2007.07.1334 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Relationship between time of reperfusion and E-selectin expression, neutrophil recruitment, and germ cell apoptosis in the ischemic testis after testicular IR in a rat. Values are mean ± SEM.∗P<.05 vs. sham. #P<.05 vs. group F (72 h). Fertility and Sterility 2008 90, 1517-1522DOI: (10.1016/j.fertnstert.2007.07.1334) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Relationship between time of reperfusion and E-selectin expression, neutrophil recruitment, and germ cell apoptosis in the contralateral testis after testicular IR in a rat. Values are mean ± SEM.∗P<.05 vs. sham. Fertility and Sterility 2008 90, 1517-1522DOI: (10.1016/j.fertnstert.2007.07.1334) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Representative sections of E-selectin expression (A), neutrophil recruitment (B), and germ cell apoptosis (C) in the contralateral testis in sham rats and after 24 hours of reperfusion. (A) Arrows indicate specific immunostaining of endothelial cells. There is no E-selectin immunoreactivity in the contralateral testis of sham rats, whereas IR rats show E-selectin–positive vessels. (B) Arrows indicate adherent polymorphonuclear (PMN) cells in subtunical venules in the contralateral testis. The number of adherent PMN cells increases after 24 hours of reperfusion, compared with sham animals. (C) Representative sections of apoptosis in the contralateral testis. Single apoptotic cells (arrows) are present in sections from sham rats. Apoptotic cells are found frequently in IR rats. Fertility and Sterility 2008 90, 1517-1522DOI: (10.1016/j.fertnstert.2007.07.1334) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions